Approaches to screening for hyperglycaemia in pregnant women during and after the COVID‐19 pandemic
| العنوان: | Approaches to screening for hyperglycaemia in pregnant women during and after the COVID‐19 pandemic |
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| المؤلفون: | David Simmons, David R. McCance, Jenny Myers, Robert S. Lindsay, Eleanor M. Scott, Helen R. Murphy, Rebecca M. Reynolds, Jennifer M. Yamamoto, Catherine E. Aiken, Claire L Meek |
| المساهمون: | Meek, CL [0000-0002-4176-8329], Aiken, CE [0000-0002-6510-5626], Reynolds, RM [0000-0001-6226-8270], Simmons, D [0000-0003-0560-0761], Yamamoto, JM [0000-0002-3556-0820], Murphy, HR [0000-0001-6876-8727], Apollo - University of Cambridge Repository |
| المصدر: | Meek, C, Lindsay, R S, Scott, E M, Aiken, C E, Myers, J, Reynolds, R M, Simmons, D, Yamamoto, J M, McCane, D R & Murphy, H R 2020, ' Approaches to screening for hyperglycaemia in pregnant women during and after the Covid-19 pandemic ', Diabetic Medicine . https://doi.org/10.1111/dme.14380 Diabetic Medicine Meek, C L, Lindsay, R S, Scott, E M, Aiken, C E, Myers, J, Reynolds, R M, Simmons, D, Yamamoto, J M, McCance, D R & Murphy, H R 2021, ' Approaches to screening for hyperglycaemia in pregnant women during and after the COVID-19 pandemic ', Diabetic Medicine, vol. 38, no. 1, e14380 . https://doi.org/10.1111/dme.14380 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Endocrinology, Diabetes and Metabolism, Hyperglycemia/diagnosis, Comorbidity, Fasting/blood, Glycated Hemoglobin A/analysis, 0302 clinical medicine, Endocrinology, Pregnancy, Risk Factors, Mass Screening, 030212 general & internal medicine, Research Articles, COVID-19/epidemiology, Glucose tolerance test, medicine.diagnostic_test, United Kingdom/epidemiology, Obstetrics, Pregnancy Outcome, Gestational age, Fasting, Gestational diabetes, Gestation, Female, Research Article, Adult, medicine.medical_specialty, Gestational Age, 030209 endocrinology & metabolism, Sensitivity and Specificity, Pregnancy Outcome/epidemiology, 03 medical and health sciences, Mass Screening/methods, Diabetes mellitus, Internal Medicine, medicine, Humans, Risk factor, Pandemics, Mass screening, Retrospective Studies, Glycated Hemoglobin, SARS-CoV-2, business.industry, COVID-19, Blood Glucose/analysis, Glucose Tolerance Test, medicine.disease, United Kingdom, Diabetes, Gestational/diagnosis, Coronavirus, Diabetes, Gestational, Hyperglycemia, business |
| الوصف: | Aim: To evaluate the diagnostic and prognostic performance of alternative diagnostic strategies to oral glucose tolerance tests, including random plasma glucose, fasting plasma glucose and HbA 1c, during the COVID-19 pandemic. Methods: Retrospective service data (Cambridge, UK; 17 736 consecutive singleton pregnancies, 2004–2008; 826 consecutive gestational diabetes pregnancies, 2014–2019) and 361 women with ≥1 gestational diabetes risk factor (OPHELIA prospective observational study, UK) were included. Pregnancy outcomes included gestational diabetes (National Institute of Health and Clinical Excellence or International Association of Diabetes and Pregnancy Study Groups criteria), diabetes in pregnancy (WHO criteria), Caesarean section, large-for-gestational age infant, neonatal hypoglycaemia and neonatal intensive care unit admission. Receiver-operating characteristic curves and unadjusted logistic regression were used to compare random plasma glucose, fasting plasma glucose and HbA 1c performance. Results: Gestational diabetes diagnosis was significantly associated with random plasma glucose at 12 weeks [area under the receiver-operating characteristic curve for both criteria 0.81 (95% CI 0.79–0.83)], fasting plasma glucose [National Institute of Health and Clinical Excellence: area under the receiver-operating characteristic curve 0.75 (95% CI 0.65–0.85); International Association of Diabetes and Pregnancy Study Groups: area under the receiver-operating characteristic curve 0.92 (95% CI 0.85–0.98)] and HbA 1c at 28 weeks' gestation [National Institute of Health and Clinical Excellence: 0.83 (95% CI 0.75–0.90); International Association of Diabetes and Pregnancy Study Groups: 0.84 (95% CI 0.77–0.91)]. Each measure predicts some, but not all, pregnancy outcomes studied. At 12 weeks, ~5% of women would be identified using random plasma glucose ≥8.5 mmol/l (sensitivity 42%; specificity 96%) and at 28 weeks using HbA 1c ≥39 mmol/mol (sensitivity 26%; specificity 96%) or fasting plasma glucose ≥5.2–5.4 mmol/l (sensitivity 18–41%; specificity 97–98%). Conclusions: Random plasma glucose at 12 weeks, and fasting plasma glucose or HbA 1c at 28 weeks identify women with hyperglycaemia at risk of suboptimal pregnancy outcomes. These opportunistic laboratory tests perform adequately for risk stratification when oral glucose tolerance testing is not available. |
| وصف الملف: | application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf |
| تدمد: | 1464-5491 0742-3071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3d798478ab1a68264b08ed90a679fc https://doi.org/10.1111/dme.14380 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ac3d798478ab1a68264b08ed90a679fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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