Gerontology
| العنوان: | Gerontology |
|---|---|
| المؤلفون: | Francisco García-García, Karine Pérès, Stefania Bandinelli, José A. Carnicero, Lee Butcher, David Gomez Cabrero, Leocadio Rodríguez-Mañas, Marco Colpo, Jorge D. Erusalimsky, Jean-François Dartigues |
| المساهمون: | Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Gerontology Gerontology, 2021, ⟨10.1159/000512287⟩ |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Aging, medicine.medical_specialty, Frail Elderly, Frail Older Adults, Population, Receptor for Advanced Glycation End Products, Disease, 050105 experimental psychology, 03 medical and health sciences, 030502 gerontology, Internal medicine, medicine, Humans, 0501 psychology and cognitive sciences, education, Aged, Proportional Hazards Models, education.field_of_study, Proportional hazards model, business.industry, 05 social sciences, 3. Good health, Increased risk, Cardiovascular Diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Risk of death, Geriatrics and Gerontology, 0305 other medical science, business, Area under the roc curve, Median survival, Biomarkers |
| الوصف: | Introduction: The evidence that blood levels of the soluble receptor for advanced glycation end products (sRAGE) predict mortality in people with cardiovascular diseases (CVD) is inconsistent. To clarify this matter, we investigated if frailty status influences this association. Methods: We analysed data of 1,016 individuals (median age, 75 years) from 3 population-based European cohorts, enrolled in the FRAILOMIC project. Participants were stratified by history of CVD and frailty status. Mortality was recorded during 8 years of follow-up. Results: In adjusted Cox regression models, baseline serum sRAGE was positively associated with an increased risk of mortality in participants with CVD (HR 1.64, 95% CI 1.09–2.49, p = 0.019) but not in non-CVD. Within the CVD group, the risk of death was markedly enhanced in the frail subgroup (CVD-F, HR 1.97, 95% CI 1.18–3.29, p = 0.009), compared to the non-frail subgroup (CVD-NF, HR 1.50, 95% CI 0.71–3.15, p = 0.287). Kaplan-Meier analysis showed that the median survival time of CVD-F with high sRAGE (>1,554 pg/mL) was 2.9 years shorter than that of CVD-F with low sRAGE, whereas no survival difference was seen for CVD-NF. Area under the ROC curve analysis demonstrated that for CVD-F, addition of sRAGE to the prediction model increased its prognostic value. Conclusions: Frailty status influences the relationship between sRAGE and mortality in older adults with CVD. sRAGE could be used as a prognostic marker of mortality for these individuals, particularly if they are also frail. |
| تدمد: | 1423-0003 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5f9c4522fb0e901ccec194aace7a6c https://pubmed.ncbi.nlm.nih.gov/33477147 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ac5f9c4522fb0e901ccec194aace7a6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230003 |
|---|