Significant Clinical Activity of Olaparib in a Somatic BRCA1-Mutated Triple-Negative Breast Cancer With Brain Metastasis
| العنوان: | Significant Clinical Activity of Olaparib in a Somatic BRCA1-Mutated Triple-Negative Breast Cancer With Brain Metastasis |
|---|---|
| المؤلفون: | Cristina Teixidó, Patricia Galván, Gisela Riu, Álvaro Urbano, Dolors Soy, Barbara Adamo, Monserrat Muñoz, Blanca Gonzalez-Farre, Gabriela Oses, Tomás Pascual, Aleix Prat, Maria Vidal, Nuria Chic, Sergi Ganau, Laura Oleaga |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | American Society of Clinical Oncology, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, Receptors d'hormones, business.industry, Somatic cell, Hormone receptors, medicine.disease, Expressió gènica, Olaparib, Càncer de mama, chemistry.chemical_compound, Breast cancer, Oncology, chemistry, medicine, Cancer research, Gene expression, skin and connective tissue diseases, business, Triple-negative breast cancer, Brain metastasis |
| الوصف: | Breast cancer is a biologically and clinically heterogeneous disease, and patients with similar clinical stage have markedly different outcomes. Triple-negative breast cancer (TNBC) is defined by the lack of expression of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 (HER2).1,2 This subtype represents 15% to 20% of all breast cancers and is associated with the worst outcome of all subtypes, with greater tendency to distant recurrence in general and visceral metastasis in particular, including brain metastasis.3,4 To date, chemotherapy remains the standard of care for TNBC |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace071a84784d360ffc85b7fa624cc4a http://hdl.handle.net/2445/178486 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ace071a84784d360ffc85b7fa624cc4a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |