The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
| العنوان: | The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells |
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| المؤلفون: | Maelle Anciaux, Mélanie Hercor, Fabienne Andris, Sébastien Denanglaire, Hind Hussein, Oberdan Leo |
| المصدر: | Frontiers in Immunology Frontiers in immunology, 8 (APR Frontiers in Immunology, Vol 8 (2017) |
| بيانات النشر: | Frontiers Media S.A., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, 0301 basic medicine, T cell, Cellular differentiation, Immunology, T cell differentiation, Biology, C-Maf, 03 medical and health sciences, follicular helper T cells, 0302 clinical medicine, Immune system, Antigen, medicine, Immunology and Allergy, Humoral response, B cell, Original Research, Germinal center, Généralités, c-Maf, BCL6, CD4+ T lymphocytes, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Follicular helper T cells, lcsh:RC581-607, humoral response, 030215 immunology |
| الوصف: | Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly,c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens. SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| DOI: | 10.3389/fimmu.2017.00480 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9b66f9a0727f1dd2c934b72f538a7b |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ad9b66f9a0727f1dd2c934b72f538a7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2017.00480 |