Supramolecular Dual Polypeptides Induced Tubulin Aggregation for Synergistic Cancer Theranostics
| العنوان: | Supramolecular Dual Polypeptides Induced Tubulin Aggregation for Synergistic Cancer Theranostics |
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| المؤلفون: | Mian Tang, Yao-Hua Liu, Hua Liu, Qiyue Mao, Qilin Yu, Hiroaki Kitagishi, Ying-Ming Zhang, Lehui Xiao, Yu Liu |
| المصدر: | Journal of Medicinal Chemistry. 65:13473-13481 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cyclodextrins, Porphyrins, Tubulin, Neoplasms, beta-Cyclodextrins, Drug Discovery, Tumor Microenvironment, Humans, Molecular Medicine, Antimitotic Agents, Precision Medicine, Peptides, Reactive Oxygen Species |
| الوصف: | The advent of macrocycle-based supramolecular chemistry can offer powerful strategies for regulating vital bioactivities in living systems and bring about emerging technology in biomedical science. Herein, we construct a supra-biomacromolecular nanosystem involving microtubules, cell-permeable porphyrins, and antimitotic peptide-decorated permethyl-β-cyclodextrins for promoting cell apoptosis in a cooperative manner. Through specific polypeptide-tubulin recognition, cyclodextrin moieties are capable of anchoring to the tubulin surface and providing abundant hydrophobic microenvironments to accommodate the photosensitive porphyrins. Consequently, spherical tubulin aggregates are formed, and reactive oxygen species can be efficiently generated via the host-guest complexation. The combined usage of complexation-promoted photodynamic efficacy and tubulin aggregation gives more serious cell apoptosis under light irradiation in vitro and in vivo. To be envisioned, this supramolecularly enhanced photodynamic performance together with controlled aggregation of natural biomacromolecules may be developed as an innovative approach to improve the therapeutic potency against many diseases. |
| تدمد: | 1520-4804 0022-2623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0d11555385af590caf97d861d44400 https://doi.org/10.1021/acs.jmedchem.2c01398 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ae0d11555385af590caf97d861d44400 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204804 00222623 |
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