Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence
| العنوان: | Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence |
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| المؤلفون: | Naohiro Okada, Rie Toriyama, Sho Kanata, Akira Sawa, Kiyoto Kasai, Syudo Yamasaki, Shinya Fujikawa, Mariko Hiraiwa-Hasegawa, Tsuyoshi Araki, Daisuke Koshiyama, Mio Masaoka, Noriaki Yahata, Peter B. Barker, Shinsuke Koike, Richard A.E. Edden, Kaori Endo, Atsushi Nishida, Kentaro Morita, Yukiko Kano, Shuntaro Ando, Noriko Sugimoto, Kingo Sawada |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, In vivo magnetic resonance spectroscopy, Adolescent, Rest, Early adolescence, Population, Prefrontal Cortex, lcsh:Medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Neural Pathways, medicine, Humans, Child, Social Behavior, Prefrontal cortex, education, lcsh:Science, gamma-Aminobutyric Acid, Anterior cingulate cortex, Brain Mapping, education.field_of_study, Multidisciplinary, medicine.diagnostic_test, business.industry, Functional connectivity, lcsh:R, Brain, Magnetic Resonance Imaging, Frontal Lobe, 030104 developmental biology, medicine.anatomical_structure, Prosocial behavior, nervous system, Female, lcsh:Q, Functional magnetic resonance imaging, business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Human prosocial behavior (PB) emerges in childhood and matures during adolescence. Previous task-related functional magnetic resonance imaging (fMRI) studies have reported involvement of the medial prefrontal cortex including the anterior cingulate cortex (ACC) in social cognition in adolescence. However, neurometabolic and functional connectivity (FC) basis of PB in early adolescence remains unclear. Here, we measured GABA levels in the ACC and FC in a subsample (aged 10.5–13.4 years) of a large-scale population-based cohort with MR spectroscopy (MEGA-PRESS) and resting-state fMRI. PB was negatively correlated with GABA levels in the ACC (N = 221), and positively correlated with right ACC-seeded FC with the right precentral gyrus and the bilateral middle and posterior cingulate gyrus (N = 187). Furthermore, GABA concentrations and this FC were negatively correlated, and the FC mediated the association between GABA levels and PB (N = 171). Our results from a minimally biased, large-scale sample provide new insights into the neurometabolic and neurofunctional correlates of prosocial development during early adolescence. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee992f335d3e7786f3eb2e9310e368c http://link.springer.com/article/10.1038/s41598-018-38355-z |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aee992f335d3e7786f3eb2e9310e368c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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