Prognostic value of von Willebrand factor in adult patients with congenital heart disease
| العنوان: | Prognostic value of von Willebrand factor in adult patients with congenital heart disease |
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| المؤلفون: | Heima Sakaguchi, Dai Suzuki, Aya Miyazaki, Hikari Miike, Toru Iwasa, Hideo Ohuchi, Nao Konagai, Michikazu Nakai, Isao Shiraishi, Yohsuke Hayama, Kimiko Nakajima, Kenichi Kurosaki |
| المصدر: | Heart. 106:910-915 |
| بيانات النشر: | BMJ, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Heart Defects, Congenital, Male, medicine.medical_specialty, Time Factors, Heart disease, 030204 cardiovascular system & hematology, Fontan Procedure, Risk Assessment, Severity of Illness Index, Young Adult, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Liver Function Tests, Von Willebrand factor, Predictive Value of Tests, Risk Factors, Internal medicine, von Willebrand Factor, Humans, Medicine, Prospective Studies, Survivors, Heart Failure, biology, business.industry, Liver Diseases, Central venous pressure, Albumin, Middle Aged, Prognosis, medicine.disease, Pathophysiology, Heart failure, biology.protein, Cardiology, Biomarker (medicine), Female, 030211 gastroenterology & hepatology, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | Objectivesvon Willebrand factor (vWF) has prognostic value in patients with heart failure (HF) and in those with liver disease. Liver congestion, due to right-sided HF (RHF), is one of the major clinical pathophysiologic manifestations in adults with congenital heart disease (ACHD). The present study’s purpose was to clarify the prognostic value of plasma levels of vWF antigen (vWF:Ag) in ACHD.MethodsWe measured vWF:Ag (%) in 382 consecutive patients (20 unrepaired cyanotic ACHD, 172 Fontan patients and 190 ACHD after biventricular repair) and compared the results with the clinical profiles and prognosis.ResultsThe plasma vWF:Ag level was 130±53 (normal range: 55%–190%), and 48 patients (13%) showed high levels of vWF:Ag (≥190%). Older age, Fontan circulation, higher central venous pressure, lower arterial oxygen saturation and lower plasma levels of albumin were independently associated with high log (vWF:Ag) (pConclusionsHigh vWF:Ag may reflect RHF severity and related liver dysfunction with a strong prognostic value of all-cause mortality in ACHD. Thus, vWF:Ag might be an excellent biomarker for monitoring ACHD with RHF. |
| تدمد: | 1468-201X 1355-6037 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af19a7b40e47ce215c57be1bd72c7f60 https://doi.org/10.1136/heartjnl-2019-316007 |
| رقم الأكسشن: | edsair.doi.dedup.....af19a7b40e47ce215c57be1bd72c7f60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468201X 13556037 |
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