Full‐length genome sequencing of RNA viruses—How the approach can enlighten us on hepatitis C and hepatitis E viruses
| العنوان: | Full‐length genome sequencing of RNA viruses—How the approach can enlighten us on hepatitis C and hepatitis E viruses |
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| المؤلفون: | Hélène Jeulin, Sibel Berger, Véronique Venard, Jean-Pierre Bronowicki, Elodie Laugel, Evelyne Schvoerer, Cédric Hartard |
| المساهمون: | Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement (LCPME), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Service de Virologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'Hépatogastroentérologie [CHRU Nancy] |
| المصدر: | Reviews in Medical Virology Reviews in Medical Virology, Wiley, 2020, ⟨10.1002/rmv.2197⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | viruses, Hepatitis C virus, Genomics, Genome, Viral, Hepacivirus, Biology, medicine.disease_cause, Genome, 03 medical and health sciences, 0302 clinical medicine, Hepatitis E virus, Virology, medicine, Animals, Humans, RNA Viruses, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Full length genome, 0303 health sciences, Whole Genome Sequencing, fungi, virus diseases, food and beverages, RNA, Hepatitis C, Hepatitis E, medicine.disease, digestive system diseases, 3. Good health, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, RNA, Viral |
| الوصف: | Among the five main viruses responsible for human hepatitis, hepatitis C virus (HCV) and hepatitis E virus (HEV) are different while sharing similarities. Both viruses can be transmitted by blood or derivatives whereas HEV can also follow environmental or zoonotic routes. These highly variable RNA viruses can cause chronic hepatitis potentially leading to hepatocarcinoma. HCV and HEV can develop new structures and functions under selective pressure to adapt to host immunity, human tissues, treatments or even various animal reservoirs. Elsewhere, with directly acting antiviral treatments, HCV can be eradicated whereas HEV is an emerging pathogen against which specific treatments have to be improved. As a unique molecular tool able to explore viral genomic plasticity, full-length genome (FLG) sequencing has become easier, faster and cheaper. The present review will show how FLG sequencing can explore these RNA viruses with the aim to investigate key genomics data to improve basic knowledge, patients' healthcare and preventive tools. |
| اللغة: | English |
| تدمد: | 1052-9276 1099-1654 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affc8e34dec4ccadd79c2e9cea7a09e8 https://hal.archives-ouvertes.fr/hal-03149680 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....affc8e34dec4ccadd79c2e9cea7a09e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10529276 10991654 |
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