Zingiber mioga Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice
| العنوان: | Zingiber mioga Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice |
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| المؤلفون: | Jeong-Moon Yun, Dakyung Kim, Minhee Lee, Jeonmin Lee, Soo-Jeung Park, Yoo-Hyun Lee |
| المصدر: | Applied Sciences Volume 11 Issue 3 Applied Sciences, Vol 11, Iss 976, p 976 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, endocrine system, Pharmacology, Hyaluronan Synthase 2, lcsh:Technology, Proinflammatory cytokine, lcsh:Chemistry, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Depigmentation, whitening, medicine, Zingiber mioga, General Materials Science, Irradiation, lcsh:QH301-705.5, Instrumentation, Wrinkle, Fluid Flow and Transfer Processes, integumentary system, biology, lcsh:T, Chemistry, Process Chemistry and Technology, Arbutin, General Engineering, lcsh:QC1-999, Computer Science Applications, Hairless, moisturizing, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, lcsh:TA1-2040, biology.protein, wrinkle improvement, medicine.symptom, lcsh:Engineering (General). Civil engineering (General), Elastin, lcsh:Physics |
| الوصف: | Here, we investigated the effects of Zingiber mioga extracts (FSH-ZM) on the moisturization and depigmentation of skin as well as wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups as follows: normal control (NC), UVB-irradiated control (C), positive control 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), positive control 2 (PC2, Arbutin 200 mg/kg b.w.), Z100 (FSH-ZM 100 mg/kg b.w.), and Z200 (FSH-ZM 200 mg/kg b.w.). The experiment spanned a period of 6 weeks. We found that FSH-ZM led to an increase in the expression of hyaluronan synthase 2, fibrillin-1, and elastin mRNAs, and showed improved skin hydration in HRM-2 hairless mice compared to that in the UVB-irradiated control group. Furthermore, FSH-ZM also inhibited the expression of inflammatory cytokines and wrinkle forming factors generated by UVB and reduced the formation of wrinkles in the test group relative to that in the control group by increasing collagen synthesis. Moreover, we found that FSH-ZM decreased the expression of melanogenesis factors, which improved depigmentation in UVB-irradiated hairless mice. These results suggest that Zingiber mioga can potentially be utilized to develop products aimed at improving skin moisturization and depigmentation and reducing wrinkle formation. |
| وصف الملف: | application/pdf |
| تدمد: | 2076-3417 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b077463e8504f2ed8e3fef9a0e2d71c9 https://doi.org/10.3390/app11030976 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b077463e8504f2ed8e3fef9a0e2d71c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763417 |
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