Background: Home noninvasive ventilation (NIV) has been increasingly used in stable chronic obstructive pulmonary disease (COPD) with chronic hypercapnic respiratory failure (CHRF). However its effectiveness remains debatable. Aim: To describe a follow-up of COPD patients under home NIV. Methods: Retrospective descriptive study based on a prospective 3-year database that included COPD patients under home NIV between August 2011 and July 2014. Results: Within the 334 patients initially screened, 109 (32.6%) had COPD with a mean ± SD post-bronchodilator FEV1 of 38.6 ± 14.9% predicted; age of 65.6 ± 9.6 years.The mean ± SD duration of ventilation was 63.4 ± 51.1 months. Heterogeneous comorbidities that can contribute to CHRF were not excluded: obstructive sleep apnea and obesity were the most prevalent.Sixty-two (56.9%) patients started NIV during admission with acute respiratory failure.During follow-up there was a significant increase in mean inspiratory positive airway pressure (IPAP) and respiratory rate (19.5 ± 4.4 vs. 23.6 ± 5.3 cmH2O and 10.7 ± 5.2 vs. 15.2 ± 1.4 breaths/min, respectively, p