Isatin: A link between natriuretic peptides and monoamines?
| العنوان: | Isatin: A link between natriuretic peptides and monoamines? |
|---|---|
| المؤلفون: | Alexei Medvedev, Merton Sandler, Angela Clow, Vivette Glover |
| المصدر: | Biochemical Pharmacology. 52:385-391 |
| بيانات النشر: | Elsevier BV, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Isatin, Pharmacology, medicine.medical_specialty, Monoamine oxidase, Chemistry, medicine.drug_class, Binding, Competitive, Biochemistry, chemistry.chemical_compound, Monoamine neurotransmitter, Endocrinology, Anxiogenic, Atrial natriuretic peptide, Internal medicine, Natriuretic peptide, medicine, Animals, Biogenic Monoamines, Tissue Distribution, Monoamine oxidase B, Receptor, Receptors, Atrial Natriuretic Factor |
| الوصف: | Isatin is an endogenous indole with a distinctive distribution in brain and tissues. In the brain, the highest levels have been found in the hippocampus (0.1 microgram/g), and an immunocytochemical stain has shown specific localization within particular cells. In vitro, its most potent known actions are as an inhibitor of monoamine oxidase B (IC50 approximately 3 microM), and of atrial natriuretic peptide (ANP) receptor binding and ANP-induced guanylate cyclase (both with an IC50 approximately 0.4 microM). In vivo, isatin administration (10-200 mg/kg) causes an increase of monoamine neurotransmitter levels in the brain. Isatin is anxiogenic in animal models at doses of 10-20 mg/kg and sedative at higher doses. Its anxiogenic effects are unlikely to be due to inhibition of monoamine oxidase, but may possibly stem from interaction with the ANP system. Isatin may mediate a link between monoamines and the natriuretic peptide system, and its analogues may provide new pharmacological tools. |
| تدمد: | 0006-2952 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90900cb0130d7924165a4cdc32159a5 https://doi.org/10.1016/0006-2952(96)00206-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b90900cb0130d7924165a4cdc32159a5 |
| قاعدة البيانات: | OpenAIRE |
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