The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls
| العنوان: | The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson’s disease and controls |
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| المؤلفون: | Carl Counsell, Cinzia Giuntoli, Qaisar Imran Khan, Jodi Maple-Grødem, Angus D. Macleod |
| المصدر: | 4288–4298 Journal of Neurology |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cohort Studies, Neurology, Medisinske Fag: 700 [VDP], Incidence, Humans, Dementia, Parkinson Disease, Prospective Studies, Neurology (clinical), Aged |
| الوصف: | Background There are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson’s disease (PD) from prospective community-based incident cohorts. Methods The PINE study prospectively identified all incident PD patients in Aberdeen along with age–sex-matched, community-based controls who consented to standardized annual life-long follow-up. Each year, a clinical expert reviewed the diagnosis of PD and the presence of dementia according to DSM-IV-based criteria. Age–sex stratified incidence rates for dementia in PD and controls were calculated and compared with hazard ratios (HR) adjusted for age, sex, education, and socioeconomic status. Cox proportional-hazard modelling was used to assess baseline predictors for PD dementia and the influence of dementia on survival and institutionalization. Results 201 patients (mean age 72.6yrs) and 260 controls (mean age 75.4yrs) were followed for median 9.5 years. The incidence of dementia was 7.4 (PD) versus 2.1 (controls) per 100 person-years (adjusted HR 6.0, 95%CI 4.1–8.7), with a sixfold increase from under 60 to over 80 years in PD but no sex difference. Independent baseline predictors of PD dementia were older age at diagnosis, self-reported cognitive symptoms, dream enactment, lower MMSE scores, worse motor UPDRS scores, and the ApoE genotype. PD dementia increased the rates of subsequent death and institutionalization (32.0 and 26.9 per 100 person-years, respectively). Conclusion The incidence of dementia in PD is high, increases markedly with age, is increased in those with baseline subjective cognitive symptoms as well as other established risk factors, and is associated with high rates of death and institutionalization. |
| وصف الملف: | application/pdf |
| تدمد: | 1432-1459 0340-5354 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de16edc09d168d7dbab0f63e6b03b3 https://doi.org/10.1007/s00415-022-11058-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b9de16edc09d168d7dbab0f63e6b03b3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321459 03405354 |
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