Pharmacological treatments of Chinese herbal medicine for irritable bowel syndrome in adults: A network meta-analysis of randomized controlled trials
| العنوان: | Pharmacological treatments of Chinese herbal medicine for irritable bowel syndrome in adults: A network meta-analysis of randomized controlled trials |
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| المؤلفون: | Ling Zhang, Huai-geng Pan, Ling Hu, Wei-jing Chen, Ruliu Li, Yun-kai Dai, Yun-bo Wu |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 8, p e0255665 (2021) |
| بيانات النشر: | Public Library of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cocos, Abdominal pain, Databases, Factual, Physiology, Network Meta-Analysis, law.invention, Geographical Locations, Irritable Bowel Syndrome, Randomized controlled trial, law, Medicine and Health Sciences, Odds Ratio, Irritable bowel syndrome, Randomized Controlled Trials as Topic, Multidisciplinary, Pharmaceutics, Body Fluids, Treatment Outcome, Research Design, Meta-analysis, Medicine, medicine.symptom, Anatomy, Research Article, Adult, medicine.medical_specialty, China, Asia, Drug Administration, Clinical Research Design, Science, Oceania, Pain, Placebo, Research and Analysis Methods, Microbiology, Signs and Symptoms, Drug Therapy, Semen, Internal medicine, medicine, Humans, Adverse effect, business.industry, Probiotics, Biology and Life Sciences, Publication bias, medicine.disease, Abdominal Pain, Strictly standardized mean difference, People and Places, Adverse Events, Clinical Medicine, business, Drugs, Chinese Herbal, Phytotherapy |
| الوصف: | Introduction Plenty of clinical studies have suggested the value of Chinese herbal medicine (CHM) for patients with irritable bowel syndrome (IBS), but their efficacy and safety have not been systematically concluded yet. This article aimed to compare and rank the therapeutic effect and safety of CHM with routine pharmacotherapies and placebo in the treatment of IBS. Methods Randomized controlled trials regarding CHM to treat IBS were searched in six databases from inception to Jan 31, 2020. A network meta-analysis was conducted to analyze the data of included publications. The quality assessment was assessed by Cochrane Handbook and GRADEpro software. The risk ratio was calculated for dichotomous outcomes while the standardized mean difference was used for continuous variables with 95% credible intervals. A Funnel plot was performed to evaluate publication bias. The surface under the cumulative ranking curve was conducted to rank the included interventions. Data were analyzed with STATA 15.0 and Review Manager 5.3. Result 3194 records were searched, and 28 eligible trials involving 3323 patients ere identified. Compared with conventional therapies and placebo, Jianpi-Chushi therapy showed significant improvement in adequate relief and IBS symptom severity scale; Shugan-Jianpi therapy showed the best efficacy in relieving the abdominal pain and abdominal distension; Wenshen-Jianpi therapy had a better effect on avoiding adverse effects and improving stool character. Conclusion This study confirmed that CHM could be beneficial for patients with IBS in relieving their clinical symptoms and should be recommended as alternative therapies. The quality of evidence in this study based on the GRADE system was “low”. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba665b45696c888863c9632ce3d3b77b http://europepmc.org/articles/PMC8345858 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ba665b45696c888863c9632ce3d3b77b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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