A novel combined prognostic nutritional index and aspartate aminotransferase-to-platelet ratio index-based score can predict the survival of patients with hepatocellular carcinoma who undergo hepatic resection
| العنوان: | A novel combined prognostic nutritional index and aspartate aminotransferase-to-platelet ratio index-based score can predict the survival of patients with hepatocellular carcinoma who undergo hepatic resection |
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| المؤلفون: | Kyohei, Yugawa, Takashi, Maeda, Shigeyuki, Nagata, Akihiro, Sakai, Makoto, Edagawa, Takahiro, Omine, Takuro, Kometani, Shohei, Yamaguchi, Kozo, Konishi, Kenkichi, Hashimoto |
| المصدر: | Surgery Today. 52:1096-1108 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Carcinoma, Hepatocellular, Nutrition Assessment, Platelet Count, Liver Neoplasms, Humans, Surgery, Aspartate Aminotransferases, General Medicine, Prognosis, Biomarkers, Retrospective Studies |
| الوصف: | Inflammation-, nutrition-, and liver fibrosis-related markers are recognized as prognostic for hepatocellular carcinoma (HCC) patients. This study, therefore, assessed the preoperative prognostic utility of the combination of these markers in patients with HCC.This single-center retrospective study included patients who underwent hepatic resection for HCC between 2004 and 2017. A total of 454 patients were divided into training (n = 334) and validation (n = 120) cohorts by random sampling. The predictive impact on surgical outcomes was evaluated using receiver operating characteristic (ROC) curves of these prognostic values in the training cohort.The prognostic nutritional index (PNI) and aspartate aminotransferase-to-platelet ratio index (APRI) were the strongest diagnostic values (areas under the ROC curves: 0.627 and 0.646, respectively). A scoring system (over 0-2 points) was developed using optimal cutoff values (for PNI 46.5 scored as 1 point; for APRI 0.98 scored as 1 point). An increased PNI-APRI score was an independent prognostic factor for both the overall and disease-free survival in HCC patients. Finally, the clinical feasibility of the PNI-APRI score was confirmed in the validation cohort.The PNI-APRI score is a useful marker for predicting surgical outcomes of HCC patients. |
| تدمد: | 1436-2813 0941-1291 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6cd803fec645ec0c0ee3d5d0cb3aee https://doi.org/10.1007/s00595-021-02440-0 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bb6cd803fec645ec0c0ee3d5d0cb3aee |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14362813 09411291 |
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