Lipofuscin: a key compound in ophthalmic practice
| العنوان: | Lipofuscin: a key compound in ophthalmic practice |
|---|---|
| المؤلفون: | Corina Cernat, Ovidiu Mușat, Edward Florian Călin, Marius-Nicolae Popescu, Cristina Patoni, Stella Ioana Popescu |
| المصدر: | Romanian Journal of Ophthalmology |
| بيانات النشر: | Romanian Society of Ophthalmology, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aging, Fluorophore, genetic structures, retinal pigment epithelium, Reviews, Retina, Lipofuscin, A2E, Pathogenesis, chemistry.chemical_compound, Retinoids, Degenerative disease, Retinal Diseases, medicine, Humans, lipofuscin, chemistry.chemical_classification, Reactive oxygen species, Retinal pigment epithelium, fundus autofluorescence, Retinal, General Medicine, medicine.disease, eye diseases, medicine.anatomical_structure, chemistry, Biochemistry, lipids (amino acids, peptides, and proteins), sense organs, Intracellular |
| الوصف: | Lipofuscin is an intracellular aging pigment with fluorescent properties, found in retinal pigment epithelium cells of the eye. It is the main fluorophore used in fundus autofluorescence imaging techniques to diagnose, describe, and follow retinal disease. Lipofuscin forms by incomplete lysosomal degradation of cellular material previously subjected to oxidative changes. A2E is the most studied fluorescent component of lipofuscin, but most of its composition remains unknown. Lipofuscin is photoreactive, generating reactive oxygen species, which may explain its role in disease development. Further knowledge is needed concerning lipofuscin genesis, biochemical composition, fluorescent compounds, and role in pathogenesis of retinal degenerative disease. |
| اللغة: | English |
| تدمد: | 2501-2533 2457-4325 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc56b7ff7b0e70af1788f09d44023296 http://europepmc.org/articles/PMC8207864 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bc56b7ff7b0e70af1788f09d44023296 |
| قاعدة البيانات: | OpenAIRE |
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