Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia
| العنوان: | Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia |
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| المؤلفون: | Mélissa Gentreau, Christelle Reynes, Robert Sabatier, Jerome J. Maller, Chantal Meslin, Jeremy Deverdun, Emmanuelle Le Bars, Michel Raymond, Claire Berticat, Sylvaine Artero |
| المساهمون: | Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Monash University [Melbourne], General Electric Healthcare [Melbourne , VIC , Australia], Australian National University (ANU), Institut d’Imagerie Fonctionnelle Humaine [CHU Montpellier] (I2FH), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) |
| المصدر: | Journal of Alzheimer's Disease Journal of Alzheimer's Disease, 2022, 89 (4), pp.1293-1302. ⟨10.3233/JAD-220490⟩ |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | hippocampus, General Neuroscience, General Medicine, Organ Size, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Amygdala, Psychiatry and Mental health, Clinical Psychology, Glucose, Alzheimer Disease, insulin resistance, glycemic load, magnetic resonance imaging, putamen, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Geriatrics and Gerontology, Gray Matter, Triglycerides, dementia |
| الوصف: | International audience; Background: Glucometabolic changes, such as high glycemic load (GL) diet and insulin resistance (IR), are potential risk factor of Alzheimer's disease (AD). Yet, the effect of these factors on brain alterations that contribute to AD pathology has not been clearly demonstrated.Objective: We aimed to assess the relationship of GL and IR with gray matter volumes involved in prodromal dementia.Methods: GL and Triglyceride-Glucose (TyG) index, an IR surrogate marker, were calculated in 497 participants who underwent magnetic resonance imaging (MRI). The gray matter volumes most related to prodromal dementia/mild cognitive impairment (diagnosed in 18/158 participants during the 7-year follow-up) were identified using a data-driven machine learning algorithm.Results: Higher GL diet was associated with reduced amygdala volume. The TyG index was negatively associated with the hippocampus, amygdala, and putamen volumes.Conclusion: These results suggest that GL and IR are associated with lower gray matter volumes in brain regions involved in AD pathology. |
| تدمد: | 1875-8908 1387-2877 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce01605820170d7c521a325376c6f3 https://pubmed.ncbi.nlm.nih.gov/36031896 |
| رقم الأكسشن: | edsair.doi.dedup.....bcce01605820170d7c521a325376c6f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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