Impaired consciousness at stroke onset in large hemisphere infarction: incidence, risk factors and outcome
| العنوان: | Impaired consciousness at stroke onset in large hemisphere infarction: incidence, risk factors and outcome |
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| المؤلفون: | Ruozhen Yuan, Deren Wang, Simiao Wu, Wendan Tao, Jie Li, Ping Zhang, Ming Liu, Junfeng Liu |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Brain Infarction, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Stroke severity, Infarction, lcsh:Medicine, Article, Stroke onset, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Atrial Fibrillation, Humans, Medicine, cardiovascular diseases, Age of Onset, lcsh:Science, Aged, Retrospective Studies, Aged, 80 and over, Multidisciplinary, business.industry, Incidence, Incidence (epidemiology), lcsh:R, Atrial fibrillation, Emergency department, Middle Aged, Prognosis, medicine.disease, Magnetic Resonance Imaging, Survival Analysis, Stroke, Clinical Practice, Impaired consciousness, 030104 developmental biology, Consciousness Disorders, Diseases of the nervous system, Female, lcsh:Q, Tomography, X-Ray Computed, business, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Impaired consciousness (IC) at stroke onset in large hemispheric infarctions (LHI) patients is common in clinical practice. However, little is known about the incidence and risk factors of IC at stroke onset in LHI. Besides, stroke-related complications and clinical outcomes in relation to the development of IC has not been systematically examined. Data of 256 consecutive patients with LHI were collected. IC at stroke onset was retrospectively collected from the initial emergency department and/or admission records. Of the 256 LHI patients enrolled, 93 (36.3%) had IC at stroke onset. LHI patients with IC at stroke onset were older (median age 66 vs. 61, p = 0.041), had shorter prehospital delay (24 vs. 26 h, p p p p p = 0.019). The IC group had higher rates of in-hospital death (23.66% vs. 11.66%, p = 0.012), 3-month mortality (49.46% vs. 24.87%, p = 0.002), and 3-month unfavorable outcome (64.51% vs. 49.07%, p = 0.017). However, after adjusting for age, baseline NIHSS score and other confounders, IC at stroke onset was not an independent predictor of in-hospital death (adjusted OR 0.56, 95% CI 0.22 to 1.47), 3-month mortality (adjusted OR 0.54, 95% CI 0.25 to 1.14) and 3-month unfavorable outcome (adjusted OR 0.64, 95% CI 0.31 to 1.33) in LHI patients (all p > 0.05). Our results suggested that IC occur in 1 out of every 3 LHI patients at stroke onset and was associated with initial stroke severity and atrial fibrillation. LHI patients with IC at stroke onset more frequently had stroke-related complications, 3-month mortality and unfavorable outcome, whereas IC was not an independent predictor of poor outcomes. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd665318fd617f9f65061c83410b0881 http://link.springer.com/article/10.1038/s41598-020-70172-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bd665318fd617f9f65061c83410b0881 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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