Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by low-grade inflammation and insulin resistance. In this process, innate immune cells play a crucial role in recognizing the stimuli (free fatty acid, lipopolysaccharide, and cytokines) and mediating the inflammatory response, contributing to the development of T2DM. Neutralizing inflammatory cytokines and blocking the inflammation cascade provide great potential for the treatment of T2DM. Here, we applied a macrophage membrane as a bait, which could specifically recognize and bind the stimuli, to encapsulate nanoparticles and capture the stimuli, further preventing inflammation. The
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