Bivalirudin started during emergency transport for primary PCI
| العنوان: | Bivalirudin started during emergency transport for primary PCI |
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| المؤلفون: | Steg, Philippe Gabriel, Van't Hof, Arnoud W.J., Hamm, Christian W., Clemmensen, Peter, Lapostolle, Frederic, Coste, Pierre, Berg, Jurrien Ten, Van Grunsven, Pierre, Eggink, Gerrit Jan, Nibbe, Lutz, Zeymer, Uwe, Campo dell' Orto, Marco, Nef, Holger, Steinmetz, Jacob, Soulat, Louis, Huber, Kurt, Deliargyris, Efthymios N., Bernstein, Debra, Schuette, Diana, Prats, Jayne, Clayton, Tim, Pocock, Stuart J., Hamon, Martial, Goldstein, Patrick, EUROMAX Investigators, Dudek, Dariusz |
| المصدر: | The New England Journal of Medicine, 369, 2207-17 The New England Journal of Medicine, 369, 23, pp. 2207-17 Steg, P G, van 't Hof, A, Hamm, C W, Clemmensen, P, Lapostolle, F, Coste, P, Ten Berg, J, Van Grunsven, P, Eggink, G J, Nibbe, L, Zeymer, U, Campo dell' Orto, M, Nef, H, Steinmetz, J, Soulat, L, Huber, K, Deliargyris, E N, Bernstein, D, Schuette, D, Prats, J, Clayton, T, Pocock, S, Hamon, M, Goldstein, P, EUROMAX Investigators & Mikkelsen, S 2013, ' Bivalirudin started during emergency transport for primary PCI ', The New England Journal of Medicine, vol. 369, no. 23, pp. 2207-17 . https://doi.org/10.1056/NEJMoa1311096 Steg, P G, van 't Hof, A, Hamm, C W, Clemmensen, P, Lapostolle, F, Coste, P, Ten Berg, J, Van Grunsven, P, Eggink, G J, Nibbe, L, Zeymer, U, Campo dell' Orto, M, Nef, H, Steinmetz, J, Soulat, L, Huber, K, Deliargyris, E N, Bernstein, D, Schuette, D, Prats, J, Clayton, T, Pocock, S, Hamon, M, Goldstein, P & EUROMAX Investigators 2013, ' Bivalirudin started during emergency transport for primary PCI ', The New England Journal of Medicine, vol. 369, no. 23, pp. 2207-17 . https://doi.org/10.1056/NEJMoa1311096 |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Emergency Medical Services, medicine.medical_treatment, Myocardial Infarction, Hemorrhage, Kaplan-Meier Estimate, Antithrombins, law.invention, Percutaneous Coronary Intervention, Randomized controlled trial, Coronary thrombosis, law, Internal medicine, Medicine, Bivalirudin, Humans, Myocardial infarction, Coronary Artery Bypass, Aged, Cardiovascular diseases [NCEBP 14], business.industry, Heparin, Coronary Thrombosis, Percutaneous coronary intervention, Anticoagulants, General Medicine, Hirudins, Middle Aged, medicine.disease, Peptide Fragments, Recombinant Proteins, Transportation of Patients, Relative risk, Conventional PCI, Cardiology, Female, Stents, business, medicine.drug |
| الوصف: | Item does not contain fulltext BACKGROUND: Bivalirudin, as compared with heparin and glycoprotein IIb/IIIa inhibitors, has been shown to reduce rates of bleeding and death in patients undergoing primary percutaneous coronary intervention (PCI). Whether these benefits persist in contemporary practice characterized by prehospital initiation of treatment, optional use of glycoprotein IIb/IIIa inhibitors and novel P2Y12 inhibitors, and radial-artery PCI access use is unknown. METHODS: We randomly assigned 2218 patients with ST-segment elevation myocardial infarction (STEMI) who were being transported for primary PCI to receive either bivalirudin or unfractionated or low-molecular-weight heparin with optional glycoprotein IIb/IIIa inhibitors (control group). The primary outcome at 30 days was a composite of death or major bleeding not associated with coronary-artery bypass grafting (CABG), and the principal secondary outcome was a composite of death, reinfarction, or non-CABG major bleeding. RESULTS: Bivalirudin, as compared with the control intervention, reduced the risk of the primary outcome (5.1% vs. 8.5%; relative risk, 0.60; 95% confidence interval [CI], 0.43 to 0.82; P=0.001) and the principal secondary outcome (6.6% vs. 9.2%; relative risk, 0.72; 95% CI, 0.54 to 0.96; P=0.02). Bivalirudin also reduced the risk of major bleeding (2.6% vs. 6.0%; relative risk, 0.43; 95% CI, 0.28 to 0.66; P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0028-4793 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be222f7dd9c1f5b962e73b6afe8f9ab5 https://ruj.uj.edu.pl/xmlui/handle/item/113481 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....be222f7dd9c1f5b962e73b6afe8f9ab5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00284793 |
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