Gut microbiome function and composition in infants from rural Kenya and association with human milk oligosaccharides
| العنوان: | Gut microbiome function and composition in infants from rural Kenya and association with human milk oligosaccharides |
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| المؤلفون: | Muriel Derrien, Nadja Mikulic, Mary A Uyoga, Empar Chenoll, Eric Climent, Adrian Howard-Varona, Suzane Nyilima, Nicole U Stoffel, Simon Karanja, Robert Kottler, Bernd Stahl, Michael B Zimmermann, Raphaëlle Bourdet-Sicard |
| المصدر: | Gut Microbes, 15 (1) |
| بيانات النشر: | Landes Bioscience, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Microbiology (medical), community types, Kenyan infants, Infectious Diseases, breastfeeding, Gastroenterology, gut microbiome, bifidobacterium, Microbiology |
| الوصف: | The gut microbiota evolves rapidly after birth, responding dynamically to environmental factors and playing a key role in short- and long-term health. Lifestyle and rurality have been shown to contribute to differences in the gut microbiome, including Bifidobacterium levels, between infants. We studied the composition, function and variability of the gut microbiomes of 6- to 11-month-old Kenyan infants (n = 105). Shotgun metagenomics showed Bifidobacterium longum to be the dominant species. A pangenomic analysis of B. longum in gut metagenomes revealed a high prevalence of B. longum subsp. infantis (B. infantis) in Kenyan infants (80%), and possible co-existence of this subspecies with B. longum subsp. longum. Stratification of the gut microbiome into community (GMC) types revealed differences in composition and functional features. GMC types with a higher prevalence of B. infantis and abundance of B. breve also had a lower pH and a lower abundance of genes encoding pathogenic features. An analysis of human milk oligosaccharides (HMOs) classified the human milk (HM) samples into four groups defined on the basis of secretor and Lewis polymorphisms revealed a higher prevalence of HM group III (Se+, Le-) (22%) than in most previously studied populations, with an enrichment in 2'-fucosyllactose. Our results show that the gut microbiome of partially breastfed Kenyan infants over the age of six months is enriched in bacteria from the Bifidobacterium community, including B. infantis, and that the high prevalence of a specific HM group may indicate a specific HMO-gut microbiome association. This study sheds light on gut microbiome variation in an understudied population with limited exposure to modern microbiome-altering factors. Gut Microbes, 15 (1) ISSN:1949-0976 ISSN:1949-0984 |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| تدمد: | 1949-0976 1949-0984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5cec7f339c625cdacd5803948b7c42 https://hdl.handle.net/20.500.11850/600537 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bf5cec7f339c625cdacd5803948b7c42 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 19490976 19490984 |
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