The Genetic Education for Men (GEM) Trial: Development of Web-Based Education for Untested Men in BRCA1/2-Positive Families
| العنوان: | The Genetic Education for Men (GEM) Trial: Development of Web-Based Education for Untested Men in BRCA1/2-Positive Families |
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| المؤلفون: | Claudine Isaacs, Aryana Jacobs, Mary Kate Ladd, Beth N. Peshkin, Kathryn L. Taylor, Hannah Segal, Suzanne C O'Neill, Marc D. Schwartz, Kristi D. Graves |
| المصدر: | J Cancer Educ |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Gerontology, medicine.medical_specialty, Genetic counseling, Breast Neoplasms, Genetic Counseling, Article, law.invention, Formative assessment, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), Humans, Medicine, Web application, Genetic Predisposition to Disease, Relevance (information retrieval), Genetic Testing, 030212 general & internal medicine, Ovarian Neoplasms, Internet, BRCA1 Protein, business.industry, Public health, Public Health, Environmental and Occupational Health, Usability, Oncology, 030220 oncology & carcinogenesis, Mutation, Female, business |
| الوصف: | Cascade testing for hereditary breast/ovarian cancer is an important public health priority. Increasing attention has been paid to the relevance of testing for men within BRCA1/2-positive families given that such testing may provide important information about their cancer risks, particularly for prostate cancer, and risks to their offspring. However, men are much less likely to seek genetic counseling and testing than their at-risk female relatives. To facilitate access to pre-test information and testing, we developed a web-based intervention (WI) for men that we are evaluating in a pilot randomized controlled trial (RCT). This paper describes three phases of research in the development of the WI: (1) formative (qualitative) research among men from BRCA1/2 families to assess needs and preferences for education; (2) a detailed description of the organization, format, and content of the WI; and (3) usability testing. We discuss the aims and hypotheses of the pilot RCT in which the WI is being compared with an enhanced usual care condition among at-risk men. We expect that the WI described here will foster informed decisions and lead to increased use of BRCA1/2 counseling and testing, potentially yielding improved cancer control outcomes for this understudied group, and for their at-risk relatives. |
| تدمد: | 1543-0154 0885-8195 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9eb4afd9c78744a3c53af30ffc38cd https://doi.org/10.1007/s13187-019-01599-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bf9eb4afd9c78744a3c53af30ffc38cd |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15430154 08858195 |
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