Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice
العنوان: | Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice |
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المؤلفون: | Haifeng Ye, Marie-Didiée Hussherr, Peter Buchmann, Ghislaine Charpin-El-Hamri, Martin Fussenegger, Krzysztof Krawczyk, Shuai Xue, Jiawei Shao, Pratik Saxena, Mingqi Xie |
المصدر: | Science Science, 368 (6494) |
سنة النشر: | 2020 |
مصطلحات موضوعية: | Bionics, Male, 0301 basic medicine, Calcium Channels, L-Type, Transcription, Genetic, medicine.medical_treatment, Transgene, Stimulation, 02 engineering and technology, Diabetes Mellitus, Experimental, Mice, 03 medical and health sciences, Insulin-Secreting Cells, Insulin Secretion, medicine, Animals, Humans, Secretion, Calcium Signaling, Transgenes, Potassium Channels, Inwardly Rectifying, Cell Engineering, Calcium signaling, Multidisciplinary, Voltage-dependent calcium channel, Chemistry, Insulin, Prostheses and Implants, 021001 nanoscience & nanotechnology, Electric Stimulation, Potassium channel, 3. Good health, Cell biology, Diabetes Mellitus, Type 1, HEK293 Cells, 030104 developmental biology, Ectopic expression, 0210 nano-technology, Wireless Technology |
الوصف: | Electronic control of designer cells There is increasing interest in using designer cells to produce or deliver therapeutics. Achieving direct communication between such cells and electronic devices would allow precise control of therapies. Krawczyk et al. describe a bioelectronic interface that uses wireless-powered electrical stimulation of cells to promote the release of insulin (see the Perspective by Brier and Dordick). The authors engineered human β cells to respond to membrane depolarization by rapidly releasing insulin from intracellular storage vesicles. A bioelectronic device that incorporates the cells can be wirelessly triggered by an external field generator. When subcutaneously implanted in type 1 diabetic mice, the device could be triggered to restore normal blood glucose levels. Science , this issue p. 993 ; see also p. 936 |
وصف الملف: | application/application/pdf |
تدمد: | 0036-8075 |
DOI: | 10.1126/science.aau7187 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38e0f12ce04f9c9b3e318fe2b7c0fb4 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....c38e0f12ce04f9c9b3e318fe2b7c0fb4 |
قاعدة البيانات: | OpenAIRE |
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