Effect of androgen deprivation therapy on serum levels of sclerostin, Dickkopf-1, and osteoprotegerin: a cross-sectional and longitudinal analysis
| العنوان: | Effect of androgen deprivation therapy on serum levels of sclerostin, Dickkopf-1, and osteoprotegerin: a cross-sectional and longitudinal analysis |
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| المؤلفون: | Nishi Karunasinghe, Sue Osborne, Tiffany Schwass, Jonathan Masters, Karen S. Bishop, Shuotun Zhu, Roger Huang, Charis Brown, Ross Lawrenson, Alice Wang, Christine Keven, Lindsay D. Plank, Sofian M. Tijono, Michael Holmes, Lynnette R. Ferguson |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Science, Urology, Article, Androgen deprivation therapy, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, 0302 clinical medicine, Endocrinology, Osteoprotegerin, Bone Density, Internal medicine, medicine, Humans, Longitudinal Studies, Testosterone, Adaptor Proteins, Signal Transducing, Bone mineral, Multidisciplinary, business.industry, Prostatic Neoplasms, Androgen Antagonists, Bone fracture, medicine.disease, 030104 developmental biology, Cross-Sectional Studies, chemistry, Oncology, 030220 oncology & carcinogenesis, Cohort, Sclerostin, Medicine, Intercellular Signaling Peptides and Proteins, Osteoporosis, business, Biomarkers |
| الوصف: | Androgen deprivation therapy (ADT) for men with prostate cancer (PCa) results in accelerated bone loss and increased risk of bone fracture. The aim of the present study was to evaluate serum bone markers—sclerostin, Dickkopf-1 (DKK-1) and osteoprotegerin (OPG), in a cohort of 88 PCa patients without known bone metastases, managed with and without ADT, and to analyse their relationship with bone mineral density (BMD) and sex steroids. The cross-sectional analysis between acute-, chronic- and former-ADT groups and PCa controls showed that sclerostin and OPG levels significantly differed between them (p = 0.029 and p = 0.032). Groups contributing to these significant changes were recorded. There were no significant differences in serum DKK-1 levels across the four groups (p = 0.683). In the longitudinal analysis, significant % decreases within groups were seen for DKK-1 [chronic-ADT (− 10.06%, p = 0.0057), former-ADT (− 12.77%, p = 0.0239), and in PCa controls group (− 16.73, p = 0.0022); and OPG levels in chronic ADT (− 8.28%, p = 0.003) and PCa controls group (− 12.82%, p = 0.017)]. However, % changes in sclerostin, DKK-1, and OPG did not differ significantly over 6-months across the evaluated groups. Sclerostin levels showed significant positive correlations with BMD at baseline in the ADT group, while in PCa controls this correlation existed at both baseline and 6-month time points. Sclerostin correlated negatively with testosterone in former ADT users and in PCa controls. Possible prognostic features denoted by parallel increases in sclerostin and BMD are discussed. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c761fefdca916d6e7467ac35cbc6b74c http://europepmc.org/articles/PMC8295319 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c761fefdca916d6e7467ac35cbc6b74c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
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