An Insight into Pathophysiological Features and Therapeutic Advances on Ependymoma
| العنوان: | An Insight into Pathophysiological Features and Therapeutic Advances on Ependymoma |
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| المؤلفون: | Jamal Uddin, Shamrat Kumar Paul, Popy Ghosh, Mita Shikder, Youngjoo Kwon, Mushira Khanam, Suranjana Sikdar, Tasnin Al Hasib, Seung Hee Seo, Kazi Ahsan Ahmed |
| المصدر: | Cancers, Vol 13, Iss 3221, p 3221 (2021) Cancers |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Ependymoma, Cancer Research, Pathology, medicine.medical_specialty, ependymoma, Ependymal Cell, Central nervous system, Brain tumor, Review, 03 medical and health sciences, 0302 clinical medicine, oncogene, Glioma, tumor treatment, medicine, RC254-282, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cerebrospinal fluid circulation, Neuroglia, Neuron, business, brain tumor, 030217 neurology & neurosurgery, tumor diagnosis |
| الوصف: | Simple Summary Although biological information and the molecular classification of ependymoma have been studied, the treatment systems for ependymoma are still insufficient. In addition, because the disease occurs infrequently, it is difficult to obtain sufficient data to conduct large-scale or randomized clinical trials. Therefore, this study is intended to emphasize the importance of understanding its pathological characteristics and prognosis as well as developing treatments for ependymoma through multilateral studies. Abstract Glial cells comprise the non-sensory parts of the central nervous system as well as the peripheral nervous system. Glial cells, also known as neuroglia, constitute a significant portion of the mammalian nervous system and can be viewed simply as a matrix of neural cells. Despite being the “Nervenkitt” or “glue of the nerves”, they aptly serve multiple roles, including neuron repair, myelin sheath formation, and cerebrospinal fluid circulation. Ependymal cells are one of four kinds of glial cells that exert distinct functions. Tumorigenesis of a glial cell is termed a glioma, and in the case of an ependymal cell, it is called an ependymoma. Among the various gliomas, an ependymoma in children is one of the more challenging brain tumors to cure. Children are afflicted more severely by ependymal tumors than adults. It has appeared from several surveys that ependymoma comprises approximately six to ten percent of all tumors in children. Presently, the surgical removal of the tumor is considered a standard treatment for ependymomas. It has been conspicuously evident that a combination of irradiation therapy and surgery is much more efficacious in treating ependymomas. The main purpose of this review is to present the importance of both a deep understanding and ongoing research into histopathological features and prognoses of ependymomas to ensure that effective diagnostic methods and treatments can be developed. |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89932b3c7f99cbf0e23e096c1f53a9b https://doi.org/10.3390/cancers13133221 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c89932b3c7f99cbf0e23e096c1f53a9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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