التفاصيل البيبلوغرافية
العنوان:
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
المؤلفون:
Duncan S. Holmes , Ann Louise Walker , Katherine Louise Jones , Chris D. Edwards , Dramane I. Laine , Don O. Somers , Paul Bamborough , Smith Kathryn Jane , Shila Patel , Jacky B. Buckton , Suzanne J. deBoeck , Richard Martyn Angell , Penny A. Smee , Nicola Mary Aston , Stuart G. Cockerill
المصدر:
Bioorganicmedicinal chemistry letters . 18(15)
سنة النشر:
2008
مصطلحات موضوعية:
Molecular model , medicine.drug_class , Stereochemistry , Clinical Biochemistry , Molecular Conformation , Pharmaceutical Science , Administration, Oral , Carboxamide , Crystallography, X-Ray , Biochemistry , Mitogen-Activated Protein Kinase 14 , chemistry.chemical_compound , In vivo , Amide , Drug Discovery , medicine , Transferase , Animals , Combinatorial Chemistry Techniques , Molecular Biology , Protein Kinase Inhibitors , chemistry.chemical_classification , Biphenyl , biology , Molecular Structure , Chemistry , Organic Chemistry , Biphenyl Compounds , Rats , Disease Models, Animal , Enzyme , Mitogen-activated protein kinase , Benzamides , biology.protein , Molecular Medicine
الوصف:
The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystallographic binding mode.
تدمد:
1464-3405
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96035dc37dc9d60b0821a85dd7535ae https://pubmed.ncbi.nlm.nih.gov/18614366
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....c96035dc37dc9d60b0821a85dd7535ae
قاعدة البيانات:
OpenAIRE
