Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI)
| العنوان: | Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI) |
|---|---|
| المؤلفون: | Félix Carvalho, Ana Margarida Araújo, Márcia Carvalho, Paula Guedes de Pinho, Maria de Lourdes Bastos |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | Taylor & Francis, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Drug, Drug-induced liver injury, media_common.quotation_subject, Pharmacology, Toxicology, Bioinformatics, Xenobiotics, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, Humans, Medicine, Biomarker discovery, Pharmaceutical industry, media_common, Liver injury, business.industry, Drug discovery, Hepatotoxicity, Urinary biomarkers, Prognosis, medicine.disease, 030104 developmental biology, Drug development, 030220 oncology & carcinogenesis, Chemical and Drug Induced Liver Injury, Conventional biomarkers, business, Biomarkers |
| الوصف: | Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is substantial. Therefore, new biomarkers for early identification of hepatotoxicity during the drug discovery process are needed, thus resulting in lower development costs and safer drugs. In this sense, metabolomics has been increasingly playing an important role in the discovery of biomarkers of liver damage, although the characterization of the mechanisms of toxicity induced by xenobiotics remains a huge challenge. These new-generation biomarkers will offer obvious benefits for the pharmaceutical industry, regulatory agencies, as well as a personalized clinical follow-up of patients, upon validation and translation into clinical practice or approval for routine use. This review describes the current status of the metabolomics applied to the early diagnosis and prognosis of DILI and in the discovery of new potential urinary biomarkers of liver injury. |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e60dbd2df50feb02ff5d7d8ce1fd90 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....c9e60dbd2df50feb02ff5d7d8ce1fd90 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |