Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
| العنوان: | Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme |
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| المؤلفون: | Alma Martelli, Antonio Giordani, Lidia Sautebin, Antonietta Rossi, Vincenzo Calderone, Lorenzo Di Cesare Mannelli, Claudio Battilocchio, Maurizio Anzini, S. Alfonso, Giulio Cesare Porretta, Giovanna Poce, Mariangela Biava, Sara Consalvi, Paola Patrignani, Carla Ghelardini, Lara Testai, Silvia Schenone |
| المساهمون: | Biava, M, Battilocchio, C, Poce, G, Alfonso, S, Consalvi, S, Porretta, Gc, Schenone, S, Calderone, V, Martelli, A, Testai, L, Ghelardini, C, Di Cesare Mannelli, L, Sautebin, Lidia, Rossi, Antonietta, Giordani, A, Patrignani, P, Anzini, M. |
| المصدر: | European Journal of Medicinal Chemistry. 58:287-298 |
| بيانات النشر: | Elsevier BV, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, analgesic and antiinflammatory acitivities, Constriction, Pathologic, COX-2, inhibitors, Pharmacology, Carrageenan, Isozyme, Muscle, Smooth, Vascular, Nitric oxide, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Acetic acid, nitric oxide, In vivo, Drug Discovery, Animals, Structure–activity relationship, Moiety, Enzyme Inhibitors, Rats, Wistar, Solubility, Acetic Acid, 5-diarylpyrroles, cinods, coxibs, cyclooxygenases, glycine derivatives, Dose-Response Relationship, Drug, Molecular Structure, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, General Medicine, Rats, Isoenzymes, chemistry, Biochemistry, Cyclooxygenase 2, Cyclooxygenases, CINODS, Coxibs, 1,5-Diarylpyrroles, Glycine derivatives, Nitric oxide |
| الوصف: | The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds. |
| تدمد: | 0223-5234 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacc1cf1a2b178e1821181459afdacf6 https://doi.org/10.1016/j.ejmech.2012.10.014 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....cacc1cf1a2b178e1821181459afdacf6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02235234 |
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