Role of micro-RNA132 and its long non coding SOX2 in diagnosis of lupus nephritis
| العنوان: | Role of micro-RNA132 and its long non coding SOX2 in diagnosis of lupus nephritis |
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| المؤلفون: | Rasha F Ahmed, Olfat Gamil Shaker, Hend M abdelghany, Nilly Helmy Abdallah, Samar Hisham Elsayed, Bothina Ahmed Kamel |
| المصدر: | Lupus. 31:89-96 |
| بيانات النشر: | SAGE Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | MicroRNAs, Rheumatology, Case-Control Studies, SOXB1 Transcription Factors, Humans, Lupus Erythematosus, Systemic, Lupus Nephritis, Biomarkers |
| الوصف: | Background The skin and the kidney are commonly affected in systemic lupus erythematosus (SLE) with similar molecular mechanisms. Although clinical indicators of renal injury in SLE are fairly uncontroversial, few biomarkers are reliable. The role of micro-RNAs (mi-RNAs) in lupus nephritis (LN) pathogenesis has been investigated to help in early diagnosis. Purpose The aim of work is to evaluate miRNA132 and SOX2 expressions in SLE Egyptian patients; with and without nephritis, and the relation between miRNA132 and its long non-coding gene SOX2 in both patients groups. Research Design This is a case-control study involving 100 SLE patients with and without LN (LN and non-LN groups), and 50 age-and sex-matched healthy controls. The study was carried out to detect miRNA132 and SOX2 expression by quantitative Real-Time Polymerase chain reaction methods. The SLE disease activity index (SLEDAI) was assessed. Results SLEDAI increased in LN compared to non-LN. Micro-RNA132 expression was significantly increased in patient groups compared to controls ( pConclusion miRNA132 and SOX2 may play a role in SLE activity and help in the early non-invasive diagnosis of LN. |
| تدمد: | 1477-0962 0961-2033 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f5d9bdf2f3b178648087502e8aef4 https://doi.org/10.1177/09612033211067166 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....cb0f5d9bdf2f3b178648087502e8aef4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770962 09612033 |
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