Relationship between LPA SNPs and inflammatory burden in patients with preeclampsia to address future cardiovascular risk
| العنوان: | Relationship between LPA SNPs and inflammatory burden in patients with preeclampsia to address future cardiovascular risk |
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| المؤلفون: | Nevin Yilmaz, Mine Kucur, Orkide Donma, Zeynep Banu Güngör, Hüseyin Sönmez, Abdullah Tuten, Hakan Ekmekçi, Ozlem Balci Ekmekci, Riza Madazli, Abdullah Serdar Acikgoz |
| المصدر: | The Journal of Maternal-Fetal & Neonatal Medicine. 34:898-906 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Inflammation, Single-nucleotide polymorphism, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Risk Factors, Internal medicine, Humans, Medicine, In patient, business.industry, Obstetrics and Gynecology, medicine.disease, Coronary heart disease, 030104 developmental biology, Cardiovascular Diseases, Heart Disease Risk Factors, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, business, Lipoprotein(a) |
| الوصف: | The study tested whether cardiovascular corresponding LPA risk genotypes improve pre-eclampsia and coronary heart disease (CHD) risk prediction beyond conventional risk factors.Studies have shown that women specific risk factors for cardiovascular disease (CVD) have taken an attention recently. It might be possible to identify women who have the highest risk in developing CVD in their further lives. It is well-known that Lp(a) levels have an impact on increased risk of CVD which is affected by LPA gene. Further, LPA risk genotypes are not considered in cardiovascular risk prediction.We have included 200 pregnant Turkish women into the study. We stratified the preeclamptic (PE) group: early (EOP) (28.7 ± 3.0 weeks) and late onset (LOP) (36.0 ± 1.4 weeks). 14 LPA SNPs were evaluated in the study. Rs9355296 and rs3798220 were found as independent risk factors for preeclampsia by logistic regression analysis. A positive correlation was found between rs9355296 and the diagnostic criteria of preeclampsia. Further rs9355296 G/* carriers have higher vascular inflammation rather than AA carriers.The findings reveal that LPA genetic variability with high inflammatory response might be an indication of future cardiovascular events. |
| تدمد: | 1476-4954 1476-7058 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8c4c8113edc141b977d1a457800e18 https://doi.org/10.1080/14767058.2019.1622667 |
| رقم الأكسشن: | edsair.doi.dedup.....cb8c4c8113edc141b977d1a457800e18 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14764954 14767058 |
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