Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma
| العنوان: | Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma |
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| المؤلفون: | Xiaodong Zhang, Haile Liu, Hao Wang, Wenting Hao, Yunguang Zhang, Qi Xin, Si Sun, Qinjuan Ren, Jiangang Xu |
| المصدر: | Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-13 (2021) Journal of Nanobiotechnology |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Traumatic brain injury, Biomedical Engineering, Metal Nanoparticles, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, Inflammation, Pharmacology, medicine.disease_cause, Gold clusters, Applied Microbiology and Biotechnology, Antioxidants, Catalysis, Mice, chemistry.chemical_compound, Morris Water Maze Test, In vivo, Brain Injuries, Traumatic, medicine, Medical technology, Animals, R855-855.5, Neurogenic inflammation, Microglia, business.industry, Superoxide, Research, Brain, Hydrogen Peroxide, medicine.disease, Catalytic activity, Mice, Inbred C57BL, Disease Models, Animal, Oxidative Stress, medicine.anatomical_structure, chemistry, Noninvasive administration, Molecular Medicine, Gold, medicine.symptom, business, Wound healing, Oxidative stress, TP248.13-248.65, Biotechnology |
| الوصف: | Background Neurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress, wound infection and immunological reactions. The emerging catalysts have shown great potential in the treatment of brain injury and neurogenic inflammation, but are limited to biosafety issues and delivery efficiency. Results Herein, we proposed the noninvasive delivery route to brain trauma by employing highly active gold clusters with enzyme-like activity to achieve the early intervention. The decomposition rate to H2O2 of the ultrasmall gold clusters is 10 times that of glassy carbon (GC) electrodes, indicating excellent catalytic activity. The gold clusters can relieve the oxidative stress and decrease the excessive O2·− and H2O2 both in vitro and in vivo. Besides, gold clusters can accelerate the wound healing of brain trauma and alleviate inflammation via inhibiting the activation of astrocytes and microglia through noninvasive adminstration. decrease the peroxide and superoxide of brain tissue. Conclusions Present work shows noninvasive treatment is a promising route for early intervention of brain trauma. |
| اللغة: | English |
| تدمد: | 1477-3155 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce76406c4a3ff10d26178567059d74c5 https://doaj.org/article/7a3e2281a5154208bde5aa8864387762 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ce76406c4a3ff10d26178567059d74c5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14773155 |
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