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Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

التفاصيل البيبلوغرافية
العنوان:	Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
المؤلفون:	Peter Walter, Jean J. Kim, Lucas C. Reineke, Sean W. Dooling, Sanjeev Khatiwada, Ping Jun Zhu, Ya Cui, Wei Li, Mauro Costa-Mattioli
المصدر:	Science. 366:843-849
بيانات النشر:	American Association for the Advancement of Science (AAAS), 2019.
سنة النشر:	2019
مصطلحات موضوعية:	Memory, Long-Term, Neuronal Plasticity, Multidisciplinary, Eukaryotic Initiation Factor-2, Brain, Translation (biology), Neurotransmission, Biology, Synaptic Transmission, Mice, Mutant Strains, Mice, eIF-2 Kinase, Eukaryotic translation, Stress, Physiological, Protein Biosynthesis, Synaptic plasticity, Neuroplasticity, Proteostasis, Animals, Initiation factor, Integrated stress response, Down Syndrome, Protein kinase A, Neuroscience
الوصف:	Tuning stress protects cognition Down syndrome (DS) is a chromosomal disorder that occurs when a person has an extra copy of chromosome 21. DS causes intellectual disabilities, among other health issues, but little is known about the mechanisms underlying the memory deficits in DS. Zhu et al. used a multidisciplinary approach to show that a defect in integrated stress response, a conserved pathway that controls protein homeostasis, can explain the cognitive and neuronal deficits in a mouse model of DS (see the Perspective by Halliday and Mallucci). These insights into the biological basis underlying DS could potentially help in the design of treatments for this condition. Science , this issue p. 843 ; see also p. 797
تدمد:	1095-9203 0036-8075
URL الوصول:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa32405b83622f67b2388f8666b5ba https://doi.org/10.1126/science.aaw5185
حقوق:	OPEN
رقم الأكسشن:	edsair.doi.dedup.....d1aa32405b83622f67b2388f8666b5ba
قاعدة البيانات:	OpenAIRE

الوصف
تدمد:	10959203 00368075