Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
العنوان: | Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome |
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المؤلفون: | Peter Walter, Jean J. Kim, Lucas C. Reineke, Sean W. Dooling, Sanjeev Khatiwada, Ping Jun Zhu, Ya Cui, Wei Li, Mauro Costa-Mattioli |
المصدر: | Science. 366:843-849 |
بيانات النشر: | American Association for the Advancement of Science (AAAS), 2019. |
سنة النشر: | 2019 |
مصطلحات موضوعية: | Memory, Long-Term, Neuronal Plasticity, Multidisciplinary, Eukaryotic Initiation Factor-2, Brain, Translation (biology), Neurotransmission, Biology, Synaptic Transmission, Mice, Mutant Strains, Mice, eIF-2 Kinase, Eukaryotic translation, Stress, Physiological, Protein Biosynthesis, Synaptic plasticity, Neuroplasticity, Proteostasis, Animals, Initiation factor, Integrated stress response, Down Syndrome, Protein kinase A, Neuroscience |
الوصف: | Tuning stress protects cognition Down syndrome (DS) is a chromosomal disorder that occurs when a person has an extra copy of chromosome 21. DS causes intellectual disabilities, among other health issues, but little is known about the mechanisms underlying the memory deficits in DS. Zhu et al. used a multidisciplinary approach to show that a defect in integrated stress response, a conserved pathway that controls protein homeostasis, can explain the cognitive and neuronal deficits in a mouse model of DS (see the Perspective by Halliday and Mallucci). These insights into the biological basis underlying DS could potentially help in the design of treatments for this condition. Science , this issue p. 843 ; see also p. 797 |
تدمد: | 1095-9203 0036-8075 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa32405b83622f67b2388f8666b5ba https://doi.org/10.1126/science.aaw5185 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....d1aa32405b83622f67b2388f8666b5ba |
قاعدة البيانات: | OpenAIRE |
تدمد: | 10959203 00368075 |
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