l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation
| العنوان: | l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation |
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| المؤلفون: | Horst Robenek, Hermann Haller, Daniel Menzel, Manfred Wilhelm |
| المصدر: | European Journal of Nutrition |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | l-Arginine, Male, Arginine, Medicine (miscellaneous), Blood Pressure, 030204 cardiovascular system & hematology, Essential hypertension, Severity of Illness Index, Body Mass Index, Cohort Studies, Prehypertension, 0302 clinical medicine, 030212 general & internal medicine, Endothelial dysfunction, Nutrition and Dietetics, Original Contribution, Blood Pressure Monitoring, Ambulatory, Middle Aged, medicine.anatomical_structure, Hypertension, Vitamin B Complex, Disease Progression, Female, Essential Hypertension, medicine.medical_specialty, Hyperhomocysteinemia, B vitamins, 03 medical and health sciences, Double-Blind Method, Internal medicine, medicine, Humans, business.industry, Endothelial function, Overweight, Atherosclerosis, medicine.disease, Blood pressure, Endocrinology, Dietary Supplements, Immunology, Vascular resistance, Vascular Resistance, Endothelium, Vascular, business, Follow-Up Studies |
| الوصف: | Purpose The aim of this trial was to investigate the influence of a dietetic product consisting of a unique combination of l-arginine with the vitamins B6, folic acid and B12 (Telcor® Arginin plus) on endothelial dysfunction. Methods Subjects aged 40–65 years with mild to moderate blood pressure (BP) elevation not treated with anti-hypertensive drugs were randomly assigned to either the dietetic product (n = 40) or a matching placebo (n = 41) for 3 months with open follow-up for a further 3 months. Postprandial change in endothelial function was assessed using the validated reactive hyperaemia index (RHI) at 3 months compared to the study onset (RHI post–pre, visit 3–visit 1; ΔΔRHI). Secondary parameters included BP and plasma homocysteine concentration. Results The primary efficacy analysis revealed superiority of the nutritional intervention over placebo (p = 0.0349) in reducing the deterioration of endothelial function. While in the active group ΔΔRHI increased (0.371 ± 0.122), almost no change could be detected in the placebo group (0.031 ± 0.100), thus demonstrating a significant improvement in vascular function in the intervention group. Moreover, the intervention reduced BP and homocysteine levels. Non-serious adverse events were equally distributed in both groups, and none of the events were assessed as possibly intervention-related by the investigators. Conclusions This trial confirmed the effective and safe use of dietary management with l-arginine in combination with B vitamins. The primary efficacy analysis demonstrated a statistically significant superiority of the combination of l-arginine with B vitamins over placebo in improving and restoring impaired endothelial function and lowering BP in patients with mild to moderate blood pressure elevation. |
| تدمد: | 1436-6215 1436-6207 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ba9117b7ff390c291deacd7745a98b https://doi.org/10.1007/s00394-016-1342-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d3ba9117b7ff390c291deacd7745a98b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14366215 14366207 |
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