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Spread of clonal linezolid-resistant Staphylococcus epidermidis in an intensive care unit associated with linezolid exposure

التفاصيل البيبلوغرافية
العنوان: Spread of clonal linezolid-resistant Staphylococcus epidermidis in an intensive care unit associated with linezolid exposure
المؤلفون: Dejan Ilic, Catherine Chirouze, Pascal Cholley, Paul Henry Wicky, Xavier Bertrand, Kevin Bouiller
المساهمون: Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
المصدر: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2020, ⟨10.1007/s10096-020-03842-7⟩
بيانات النشر: HAL CCSD, 2020.
سنة النشر: 2020
مصطلحات موضوعية: 0301 basic medicine, Male, Antibiotic resistance, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Medical microbiology, law, Staphylococcus epidermidis, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, Blood culture, 030212 general & internal medicine, Cross Infection, Molecular Epidemiology, biology, medicine.diagnostic_test, General Medicine, Middle Aged, Staphylococcal Infections, Intensive care unit, 3. Good health, Anti-Bacterial Agents, Intensive Care Units, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Female, Microbiology (medical), DNA, Bacterial, medicine.medical_specialty, Genotyping, Genotype, 030106 microbiology, Microbial Sensitivity Tests, 03 medical and health sciences, Internal medicine, Drug Resistance, Bacterial, Pulsed-field gel electrophoresis, Humans, Aged, business.industry, Linezolid, biology.organism_classification, chemistry, Risk factors, Case-Control Studies, Multilocus sequence typing, business
الوصف: International audience; The aim of the study was to determine factors associated with spread of linezolid (LNZ)-resistant Staphylococcus epidermidis isolates in a surgical intensive care unit (ICU). A case-control study was conducted in one French adult surgical ICU. From January 2012 to December 2016, patients with at least a single positive LNZ-resistant S. epidermidis blood culture were matched to control with LNZ-susceptible S. epidermidis blood culture in a 1:4 manner. Cases were compared to controls regarding baseline clinical characteristics and LNZ exposure before positive blood culture. Bacterial isolates were genotyped by using pulsed-field gel electrophoresis (PFGE) and MLST. We identified 13 LNZ-resistant S. epidermidis isolates, 1 in 2012, 3 in 2014, 6 in 2015, and 3 in 2016. LNZ use increased steadily from 8 DDDs/100 patient days in 2010 to 19 in 2013 and further decrease by more of 50% in 2015 and 2016. The only independent risk factors associated to LNZ-resistant S. epidermidis isolation were length of stay in ICU before infection (OR 1.45; 95% CI 1.07-1.98), prior exposure to LNZ (OR 109; 95% CI 3.9-3034), and Charlson comorbidities score (OR 3.19; 95% CI 1.11-9.14). PFGE typing showed that all LNZ-resistant isolates were clonal belonging to ST2 and that LNZ-susceptible isolates were highly diverse. We report herein that previous exposure to LNZ substantially increased the risk of occurrence of LNZ resistance in S. epidermidis even in the case of clonal spread of LNZ-resistant isolates. These findings highlight the need for reducing the use of LNZ to preserve its efficacy in the future.
اللغة: English
تدمد: 0934-9723
1435-4373
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43eb323936d137a7e8b1666cd0708b1
https://hal.archives-ouvertes.fr/hal-02540788
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....d43eb323936d137a7e8b1666cd0708b1
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09349723
14354373