Combined vascular and extracellular pH imaging of solid tumors
| العنوان: | Combined vascular and extracellular pH imaging of solid tumors |
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| المؤلفون: | Meiyappan Solaiyappan, Sebastián Cerdán, Robert J. Gillies, Zaver M. Bhujwalla, Paloma Ballesteros, Dmitri Artemov |
| المساهمون: | Army Medical Research and Materiel Command (US), National Institutes of Health (US), Susan G. Komen Foundation |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Gadolinium DTPA, Pathology, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Ratón, education, Transplantation, Heterologous, Mammary gland, Contrast Media, Breast Neoplasms, Metastasis, Mice, Breast cancer, Image Processing, Computer-Assisted, Tumor Cells, Cultured, medicine, Extracellular, Animals, Humans, Radiology, Nuclear Medicine and imaging, Neoplasm Metastasis, Solid tumor, health care economics and organizations, Spectroscopy, Phantoms, Imaging, business.industry, Cancer, Hydrogen-Ion Concentration, Hypoxia (medical), medicine.disease, medicine.anatomical_structure, Blood Vessels, Molecular Medicine, Female, medicine.symptom, business |
| الوصف: | The unique physiological environment of solid tumors, frequently characterized by areas of poor flow, hypoxia, high lactate and low extracellular pH (pHe), influences vascularization, invasion and metastasis. Thus, vascularization and the physiological and metabolic environment play permissive (and conversely preventive) roles in invasion and metastasis. By using a multi-parametric approach of combined vascular and spectroscopic imaging, we can begin to evaluate which combinations of vascular, metabolic and physiological regions in a solid tumor represent the highest 'metastatic threat'. Here, we present measurements of pHe, vascular volume and permeability from colocalized regions within a solid tumor. These studies were performed for a group of metastatic (MDA-MB-231) and non-metastatic (MCF-7) human breast cancer xenografts. In this study, we have demonstrated the feasibility of such an approach, and presented methods of analyses to detect differences in patterns of combined parameters obtained from spatially co-registered regions in a solid tumor. Copyright © 2002 John Wiley & Sons, Ltd. Contract/grant sponsor: USAMRMC; contract grant number: DAMD 17-96-1-6131. Contract/grant sponsor: Susan G. Komen Foundation. Contract/grant sponsor: NIH; contract grant number: R01 CA73850; contract grant number: R01 CA77575; contract grant number: R01 CA82337; contract grant number: P20 CA86346. |
| تدمد: | 1099-1492 0952-3480 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c832def7d35e0627c6c58ce98fc530 https://doi.org/10.1002/nbm.743 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d5c832def7d35e0627c6c58ce98fc530 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991492 09523480 |
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