The structure of a subterminal repeated sequence present on many human chromosomes
| العنوان: | The structure of a subterminal repeated sequence present on many human chromosomes |
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| المؤلفون: | Sally H. Cross, Howard J. Cooke, Stewart McKay, Niolette I. McGill, Janet C. Lindsey, J Fantes |
| المصدر: | Nucleic Acids Research. 18:6649-6657 |
| بيانات النشر: | Oxford University Press (OUP), 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Genetics, Base Composition, Base Sequence, Genetic Complementation Test, Molecular Sequence Data, Restriction Mapping, Nucleic acid sequence, DNA, Molecular cloning, Biology, Chromosomes, Telomere, chemistry.chemical_compound, Restriction map, Gene mapping, chemistry, Sequence Homology, Nucleic Acid, Yeasts, Humans, Cloning, Molecular, Primer (molecular biology), Repeated sequence, Repetitive Sequences, Nucleic Acid |
| الوصف: | All telomeres which have been studied consist of an array of simple G/C rich repeats. Human telomeres were shown to share sequence similarity with those of lower eukaryotes by cross-hybridization and human telomeric sequences have been cloned by complementation of telomere function in yeast. Analysis of human telomeric sequences cloned in this way is described here. The terminal part of the cloned human telomeric DNA consists of an array of simple repeats, principally of the sequence TTAGGG and derivatives. The very terminal part consists of yeast-type telomeric repeats which suggests that the human telomeric sequences have acted as a primer for the addition of additional telomeric repeats in the yeast. Subterminal sequences are shared between a number of clones and in situ data shows that these subterminal sequences are present at several different chromosomal ends. Related sequences are present at internal as well as telomeric positions. Differences in the hybridization patterns of subterminal sequences in somatic compared to germ-line tissues are described which indicate differential modification of these sequences during development. |
| تدمد: | 1362-4962 0305-1048 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74ec9a2bc261aa2565d932366622135 https://doi.org/10.1093/nar/18.22.6649 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d74ec9a2bc261aa2565d932366622135 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13624962 03051048 |
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