Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases
| العنوان: | Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseases |
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| المؤلفون: | K. L. Meena, Satyavati Rana, Nikita Sandhu |
| المصدر: | Molecular Biology Reports. 48:8155-8170 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Orphan receptor, endocrine system, Subfamily, Base Sequence, Liver receptor homolog-1, Receptors, Cytoplasmic and Nuclear, Cell Differentiation, General Medicine, Biology, Ligands, Orphan Nuclear Receptors, Ligand (biochemistry), medicine.disease, Embryonic stem cell, Cell biology, Nuclear receptor, Pancreatic cancer, Phosphatidylcholines, Genetics, medicine, Animals, Humans, Haploinsufficiency, Molecular Biology, Phospholipids |
| الوصف: | Nuclear receptors are the regulatory molecules that mediate cellular signals as they interact with specific DNA sequences. NR5A2 is a member of NR5A subfamily having four members (Nr5a1-Nr5a4). NR5A2 shows involvement in diverse biological processes like reverse cholesterol transport, embryonic stem cell pluripotency, steroidogenesis, development and differentiation of embryo, and adult homeostasis. NR5A2 haploinsufficiency has been seen associated with chronic pancreatitis, pancreatic and gastrointestinal cancer. There is a close relationship between the progression of pancreatic cancer from chronic pancreatitis, NR5A2 serving a common link. NR5A2 activity is regulated by intracellular phospholipids, transcriptional coregulators and post-translational modifications. The specific ligand of NR5A2 is unknown hence called an orphan receptor, but specific phospholipids such as dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine act as a ligand and they are established drug targets in various diseases. This review will focus on the NR5A2 structure, regulation of its activity, and role in biological processes and diseases. In future, need more emphasis on discovering small molecule agonists and antagonist, which act as a drug target for therapeutic applications. |
| تدمد: | 1573-4978 0301-4851 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f6dba18f234f0239ee701fb1201a48 https://doi.org/10.1007/s11033-021-06784-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....d7f6dba18f234f0239ee701fb1201a48 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15734978 03014851 |
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