COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese–Western Medicine for the Management of 2019 Novel Coronavirus Disease
| العنوان: | COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese–Western Medicine for the Management of 2019 Novel Coronavirus Disease |
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| المؤلفون: | Kam Wa Chan, Vivian Taam Wong, Sydney C.W. Tang |
| المصدر: | The American Journal of Chinese Medicine |
| بيانات النشر: | World Scientific Pub Co Pte Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, myalgia, medicine.medical_specialty, Pneumonia, Viral, MEDLINE, Traditional Chinese medicine, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, 030212 general & internal medicine, Medicine, Chinese Traditional, Intensive care medicine, Pandemics, Clinical Trials as Topic, Integrative Medicine, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, General Medicine, Clinical trial, Regimen, 030104 developmental biology, Complementary and alternative medicine, Practice Guidelines as Topic, Integrative medicine, medicine.symptom, Coronavirus Infections, business |
| الوصف: | As of 22 February 2020, more than 77662 cases of confirmed COVID-19 have been documented globally with over 2360 deaths. Common presentations of confirmed cases include fever, fatigue, dry cough, upper airway congestion, sputum production, shortness of breath, myalgia/arthralgia with lymphopenia, prolonged prothrombin time, elevated C-reactive protein, and elevated lactate dehydrogenase. The reported severe/critical case ratio is approximately 7–10% and median time to intensive care admission is 9.5–10.5 days with mortality of around 1–2% varied geographically. Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. We have also reviewed the clinical evidence generated from SARS and H1N1 management with hypothesized mechanisms and latest in silico findings to identify candidate Chinese medicines for the consideration of possible trials and management. Given the paucity of strongly evidence-based regimens, the available data suggest that Chinese medicine could be considered as an adjunctive therapeutic option in the management of COVID-19. |
| تدمد: | 1793-6853 0192-415X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85446ff4207af845d77f7da155f807b https://doi.org/10.1142/s0192415x20500378 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....d85446ff4207af845d77f7da155f807b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17936853 0192415X |
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