التفاصيل البيبلوغرافية
| العنوان: |
Peroxisomal metabolism and oxidative stress |
| المؤلفون: |
Marc Fransen, Marcus Nordgren |
| المصدر: |
Biochimie. 98 |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
Aging, hydrogen peroxide, Oxidative phosphorylation, Mitochondrion, Biology, medicine.disease_cause, Biochemistry, Second Messenger Systems, age-related diseases, lipid metabolism, mitochondrial dysfunction, medicine, Peroxisomes, oxidative stress, Animals, Humans, redox signaling, Cellular Senescence, chemistry.chemical_classification, Reactive oxygen species, Neurodegeneration, peroxisomes, Lipid metabolism, General Medicine, Peroxisome, medicine.disease, Lipid Metabolism, Cell biology, Mitochondria, Oxidative Stress, chemistry, lipid second messenger, Signal transduction, Reactive Oxygen Species, Oxidation-Reduction, Oxidative stress, Signal Transduction |
| الوصف: |
Peroxisomes are ubiquitous and multifunctional organelles that are primarily known for their role in cellular lipid metabolism. As many peroxisomal enzymes catalyze redox reactions as part of their normal function, these organelles are also increasingly recognized as potential regulators of oxidative stress-related signaling pathways. This in turn suggests that peroxisome dysfunction is not only associated with rare inborn errors of peroxisomal metabolism, but also with more common age-related diseases such as neurodegeneration, type 2 diabetes, and cancer. This review intends to provide a comprehensive picture of the complex role of mammalian peroxisomes in cellular redox metabolism. We highlight how peroxisomal metabolism may contribute to the bioavailability of important mediators of oxidative stress, with particular emphasis on reactive oxygen species. In addition, we review the biological properties of peroxisome-derived signaling messengers and discuss how these molecules may mediate various biological responses. Furthermore, we explore the emerging concepts that peroxisomes and mitochondria share an intricate redox-sensitive relationship and cooperate in cell fate decisions. This is particularly relevant to the observed demise of peroxisome function which accompanies cellular senescence, organismal aging, and age-related diseases. publisher: Elsevier articletitle: Peroxisomal metabolism and oxidative stress journaltitle: Biochimie articlelink: http://dx.doi.org/10.1016/j.biochi.2013.07.026 content_type: article copyright: Copyright © 2013 Elsevier Masson SAS. All rights reserved. ispartof: Biochimie vol:98 issue:1 pages:56-62 ispartof: location:France status: published |
| وصف الملف: |
Print-Electronic |
| تدمد: |
1638-6183 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fb5f65b28b351656f62e20f34dbb4c
https://pubmed.ncbi.nlm.nih.gov/23933092 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....d8fb5f65b28b351656f62e20f34dbb4c |
| قاعدة البيانات: |
OpenAIRE |
