The Concavity of the Maximal Expiratory Flow–Volume Curve Reflects the Extent of Emphysema in Obstructive Lung Diseases
| العنوان: | The Concavity of the Maximal Expiratory Flow–Volume Curve Reflects the Extent of Emphysema in Obstructive Lung Diseases |
|---|---|
| المؤلفون: | Shigeo Muro, Susumu Sato, Hiroaki Iijima, Nobuyuki Hizawa, Hironori Masuko, Naoya Tanabe, Keiji Fujiwara, Masanari Shiigai, Hiroichi Ishikawa, Azusa Watanabe, Tohru Sakamoto, Yohei Yatagai, Jun Kanazawa, Fumi Mochizuki, Takafumi Shimada |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Spirometry, Male, medicine.medical_specialty, Vital capacity, lcsh:Medicine, Sensitivity and Specificity, Severity of Illness Index, Article, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Internal medicine, Severity of illness, medicine, Humans, 030212 general & internal medicine, lcsh:Science, Lung, Asthma, Aged, Maximal Expiratory Flow-Volume Curves, COPD, Multidisciplinary, medicine.diagnostic_test, business.industry, Chronic obstructive pulmonary disease, lcsh:R, Volume Curve, Middle Aged, medicine.disease, MEFV, Respiratory Function Tests, respiratory tract diseases, medicine.anatomical_structure, 030228 respiratory system, Pulmonary Emphysema, Cardiology, Female, lcsh:Q, business, Tomography, X-Ray Computed |
| الوصف: | A concave-shaped maximal expiratory flow-volume (MEFV) curve is a spirometric feature in chronic obstructive pulmonary disease (COPD). The MEFV curve is characterized by an increase in the Obstructive Index, which is defined as a ratio of forced vital capacity to the volume-difference between two points of half of the peak expiratory flow on the MEFV curve. We hypothesized that the Obstructive Index would reflect the severity of emphysema in patients with COPD and asthma-COPD overlap (ACO). Thus, the aim of this retrospective study was to evaluate whether the Obstructive Index on spirometry is associated with the extent of emphysema on computed tomography (CT) in patients with COPD, ACO, and asthma (N = 65, 15, and 53, respectively). The percentage of low-attenuation volume (LAV%) and wall area (WA%) were measured on CT. The Obstructive Index was higher in patients with COPD and ACO than in those with asthma. Spearman correlation showed that a greater Obstructive Index was associated with a higher LAV%, but not WA%. Multivariate analysis showed that Obstructive Index was associated with LAV% (standardized β = 0.43, P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4576042c05ea17d45a2f32c210c48b http://link.springer.com/article/10.1038/s41598-019-49591-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....da4576042c05ea17d45a2f32c210c48b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|