التفاصيل البيبلوغرافية
| العنوان: |
PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD |
| المؤلفون: |
Jennifer Tsai, Michel Sadelain, Marcel R.M. van den Brink, Hae Lee, Amanda M. Holland, Nury L. Yim, George F. Murphy, Chen Liu, Derek B. Sant'Angelo, Cecilia Lezcano, Alan M. Hanash, Uttam K. Rao, Il-Kang Na, Martin Sauer, Lauren F. Young, Mallory L. West, Natalie V. Singer, Robert R. Jenq, Arnab Ghosh, Olaf Penack, Yildirim Dogan |
| المصدر: |
Cancer research. 73(15) |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
Cancer Research, Adoptive cell transfer, medicine.medical_treatment, T cell, T-Lymphocytes, Kruppel-Like Transcription Factors, Graft vs Host Disease, Biology, Lymphocyte Activation, Article, Flow cytometry, Mice, Homologous chromosome, medicine, Animals, Transplantation, Homologous, Promyelocytic Leukemia Zinc Finger Protein, Transcription factor, Bone Marrow Transplantation, Mice, Inbred BALB C, medicine.diagnostic_test, Effector, Graft vs Tumor Effect, Neoplasms, Experimental, Flow Cytometry, Adoptive Transfer, Transplantation, Mice, Inbred C57BL, Cytokine, medicine.anatomical_structure, surgical procedures, operative, Oncology, Immunology, Lymphocyte Culture Test, Mixed |
| الوصف: |
Efforts to limit GVHD mediated by alloreactive donor T cells after allogeneic bone marrow transplantation are limited by a concomitant decrease in graft-versus-tumor (GVT) activity and increased possibilities of tumor relapse. Using a novel approach, we adoptively transferred conventional T cells expressing the transcription factor promyelocytic leukemia zinc finger (PLZF), which confers effector properties resembling invariant natural killer T cells, such as copious production of cytokines under suboptimal stimulation. PLZF expression in T-cell allografts attenuates expansion of alloreactive T cells, leading to lower GVHD. Intact alloreactivity-driven antitumor cytokine responses result in preserved GVT effects, leading to improved survival. Our findings suggest that therapy with PLZF-overexpressing T cells would result in overall improved outcomes due to less GVHD and intact GVT effects. Cancer Res; 73(15); 4687–96. ©2013 AACR. |
| تدمد: |
1538-7445 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4a2b5467c18a8fd9491457e48a9d01
https://pubmed.ncbi.nlm.nih.gov/23733752 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....db4a2b5467c18a8fd9491457e48a9d01 |
| قاعدة البيانات: |
OpenAIRE |
