Sparse Reconstruction of Fluorescence Molecular Tomography Using Variable Splitting and Alternating Direction Scheme
| العنوان: | Sparse Reconstruction of Fluorescence Molecular Tomography Using Variable Splitting and Alternating Direction Scheme |
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| المؤلفون: | Shixin Jiang, Yang Du, Xin Yang, Chongwei Chi, Kunshan He, Kun Wang, Yamin Mao, Jie Tian, Yu An, Wenting Shang, Jinzuo Ye |
| المصدر: | Molecular Imaging and Biology. 20:37-46 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Optimization problem, Computer science, Mice, Nude, 01 natural sciences, Fluorescence, 030218 nuclear medicine & medical imaging, 010309 optics, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Robustness (computer science), 0103 physical sciences, Convergence (routing), Image Processing, Computer-Assisted, medicine, Animals, Radiology, Nuclear Medicine and imaging, Medical physics, Tomography, Computer simulation, Augmented Lagrangian method, Inverse problem, Oncology, Tomography, X-Ray Computed, Algorithm, Algorithms, Preclinical imaging |
| الوصف: | Fluorescence molecular tomography (FMT) is a novel imaging modality for three-dimensional preclinical research and has many potential applications for drug therapy evaluation and tumor diagnosis. However, FMT presents an ill-conditioned and ill-posed inverse problem, which is a challenge for its tomography reconstruction. Due to the importance of FMT reconstruction, it is valuable and necessary to develop further practical reconstruction methods for FMT. In this study, an efficient method using variable splitting strategy as well as alternating direction strategy (VSAD) was proposed for FMT reconstruction. In this method, the variable splitting strategy and the augmented Lagrangian function were first introduced to obtain an equivalent optimization formulation of the original problem. Then, the alternating direction scheme was used to solve the optimization problem and to accelerate its convergence. To examine the property of the VSAD method, three numerical simulation experiments (accuracy assessment experiment, robustness assessment experiment, and reconstruction speed assessment experiment) were performed and analyzed. The results indicated that the reconstruction accuracy, the reconstruction robustness, and the reconstruction speed of FMT were satisfactory by using the proposed VSAD method. Two in vivo studies, which were conducted by using two nude mouse models, further confirmed the advantages of the proposed method. The results indicated that the proposed VSAD algorithm is effective for FMT reconstruction. It was accurate, robust, and efficient for FMT imaging and was feasibly applied for in vivo FMT applications. |
| تدمد: | 1860-2002 1536-1632 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccf4e4fcf365a52bc46d1a3adcae015 https://doi.org/10.1007/s11307-017-1088-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....dccf4e4fcf365a52bc46d1a3adcae015 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18602002 15361632 |
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