Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis
| العنوان: | Diagnostic and prognostic value of miRNAs on salivary gland tumors: a systematic review and meta-analysis |
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| المؤلفون: | Fernanda Viviane Mariano, Lívia Ramalho Crescencio, João Figueira Scarini, Reydson Alcides de Lima-Souza, Adriana Franco Paes Leme, Ana Gabriela Costa Normando, Erison Santana dos Santos |
| المصدر: | Oral and Maxillofacial Surgery. 25:445-456 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, Mirna expression, Internal medicine, microRNA, Biomarkers, Tumor, medicine, Humans, 030223 otorhinolaryngology, Salivary gland, Quality assessment, business.industry, Hazard ratio, Diagnostic marker, 030206 dentistry, Prognosis, Salivary Gland Neoplasms, Confidence interval, MicroRNAs, medicine.anatomical_structure, Otorhinolaryngology, Meta-analysis, Surgery, Oral Surgery, business |
| الوصف: | Different levels of miRNA expression have been described in salivary gland tumors as a potential diagnostic marker and predictor of survival. We systematically reviewed the literature to assess the diagnostic and prognostic value of miRNAs on salivary gland tumors. An electronic search was conducted in PubMed, Scopus, Embase, Cochrane, and Web of Science databases. In the meta-analysis, we assumed random-effects model with adjusted hazard ratio (HR) and 95% confidence intervals (95% CI). For prognostic studies, the risk of bias was assessed by Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) and Quality Assessment Tool for Diagnostic Accuracy Studies-2 (QUADAS-2) was utilized for diagnostic studies. Gathered data from 1.131 patients in seven studies demonstrated that different levels of miRNA expression presented diagnostic and prognostic in SGTs. The meta-analysis showed that altered miRNA expression were associated with shortened survival (HR, 2.35, 95% CI, 1.77–3.10, P < .00001). For diagnostic meta-analysis, the overall pooled results for specificity and sensibility were 0.87–0.97 (95% CI, 0.72–1) and 0.68–0.91 (95% CI, 0.51–0.96), respectively. MicroRNAs may be useful in prognostication of patients with SGTs; however, the diagnostic value of miRNAs in SGTs is still limited. |
| تدمد: | 1865-1569 1865-1550 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd635ca6e2595bef99c528c66d31fc14 https://doi.org/10.1007/s10006-021-00952-0 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....dd635ca6e2595bef99c528c66d31fc14 |
| قاعدة البيانات: | OpenAIRE |
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