Gut microbiota impacts bone via B.vulgatus-valeric acid-related pathways
العنوان: | Gut microbiota impacts bone via B.vulgatus-valeric acid-related pathways |
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المؤلفون: | Jie Shen, Yuan-Cheng Chen, Zhi Chen, Hui Shen, Chang-Li Ge, Jonathan Greenbaum, Zhang-Fang Li, Zeng-Xin Ao, Cheng Peng, Qiang Zhang, Rui Gong, Xu Lin, Yin-Hua Zhang, Xingming Shi, Christopher J. Papasian, Si-Jie Yuan, Nengjun Yi, Dao-Yan Pan, Kuan-Jui Su, Feng-Ye Lv, Hui-Min Liu, Xiang-He Meng, Boyi Guo, Rou Zhou, Wan-Qiang Lv, Jun-Min Lu, Xuejuan Xu, Hong-Wen Deng, Qi Zhao, Yu-Qian Song, Hong-Mei Xiao, Xia-Fang Wang |
بيانات النشر: | Cold Spring Harbor Laboratory, 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | 2. Zero hunger, Bone mineral, 0303 health sciences, medicine.medical_specialty, Valeric acid, biology, Osteoporosis prevention, Gut flora, biology.organism_classification, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, fluids and secretions, chemistry, Internal medicine, Ovariectomized rat, medicine, Protein biosynthesis, 030217 neurology & neurosurgery, 030304 developmental biology, Targeted metabolomics |
الوصف: | Although gut microbiota influences osteoporosis risk, the individual species involved, and underlying mechanisms, are unknown. We performed integrative analyses in a Chinese cohort with metagenomics/targeted metabolomics/whole-genome sequencing. Bacteroides vulgatus was found negatively associated with bone mineral density (BMD), this association was validated in US Caucasians. Serum valeric acid was positively associated with BMD, and B.vulgatus causally downregulated it. Ovariectomized mice fed B.vulgatus had decreased bone formation and increased bone resorption, lower BMD and poorer bone micro-structure. Valeric acid suppressed NF-κB p65 protein production (pro-inflammatory), and enhanced IL-10 mRNA expression (anti-inflammatory), leading to suppressed maturation of osteoclast-like cells, and enhanced maturation of osteoblasts in vitro. B.vulgatus and valeric acid represent promising targets for osteoporosis prevention/treatment. |
اللغة: | English |
DOI: | 10.1101/2020.03.16.20037077 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df781f92cd4c3a839a68c2c861f0284d |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....df781f92cd4c3a839a68c2c861f0284d |
قاعدة البيانات: | OpenAIRE |
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