False Elevation of the Blood Tacrolimus Concentration, as Assessed by an Affinity Column-mediated Immunoassay (ACMIA), Led to Acute T Cell-mediated Rejection after Kidney Transplantation
العنوان: | False Elevation of the Blood Tacrolimus Concentration, as Assessed by an Affinity Column-mediated Immunoassay (ACMIA), Led to Acute T Cell-mediated Rejection after Kidney Transplantation |
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المؤلفون: | Ayumi Ishiwatari, Jumpei Hasegawa, Kazunari Tanabe, Kanae Yoshikawa, Sachiko Wakai, Hina Ogawa, Hiroki Shirakawa, Momoko Kono |
المصدر: | Internal Medicine |
سنة النشر: | 2017 |
مصطلحات موضوعية: | Adult, Graft Rejection, Male, medicine.medical_specialty, T cell, T-Lymphocytes, Urology, kidney transplantation, chemical and pharmacologic phenomena, Case Report, 030230 surgery, 030226 pharmacology & pharmacy, Methylprednisolone, Chromatography, Affinity, Tacrolimus, 03 medical and health sciences, 0302 clinical medicine, Therapeutic index, Affinity chromatography, Enzyme Multiplied Immunoassay Technique, Internal Medicine, Medicine, Humans, Kidney transplantation, Antilymphocyte Serum, affinity column mediated immunoassay, medicine.diagnostic_test, business.industry, General Medicine, T cell-mediated rejection, medicine.disease, medicine.anatomical_structure, surgical procedures, operative, Treatment Outcome, Immunoassay, Immunoassay technique, ACMIA, business, Immunosuppressive Agents, medicine.drug |
الوصف: | Tacrolimus is the most commonly used immunosuppressant. Because of its narrow therapeutic range, it is necessary to frequently monitor its concentration. We report the case of a 25-year-old man who underwent kidney transplantation whose tacrolimus concentrations, as measured by an affinity column-mediated immunoassay, were falsely elevated. As we reduced the dose of tacrolimus, the recipient developed T cell-mediated rejection. Using the same blood samples, an enzyme-multiplied immunoassay technique showed that the patient's levels of tacrolimus were extremely low. A further examination indicated that the false increase in the tacrolimus concentration was likely due to an unknown interfering substance. We administered methylprednisolone and antithymocyte-globulin. The patient's serum creatinine level decreased and remained stable after these treatments. |
تدمد: | 1349-7235 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b162c654e926c6059e234339151fbc https://pubmed.ncbi.nlm.nih.gov/29279473 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....e0b162c654e926c6059e234339151fbc |
قاعدة البيانات: | OpenAIRE |
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