Synthesis and characterization of silver nanoparticles decorated polydopamine coated hexagonal boron nitride and its effect on wound healing
العنوان: | Synthesis and characterization of silver nanoparticles decorated polydopamine coated hexagonal boron nitride and its effect on wound healing |
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المؤلفون: | Melis Emanet Ciofani, Özlem Şen, Deniz Yılmaz, Mustafa Culha, Tuba Tarhan |
المساهمون: | Sağlık Hizmetleri Meslek Yüksekokulu |
بيانات النشر: | Journal of Trace Elements in Medicine and Biology, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Boron Compounds, Indoles, Silver, Biocompatibility, Polymers, Metal Nanoparticles, Context (language use), 010501 environmental sciences, 01 natural sciences, Biochemistry, Silver nanoparticle, Inorganic Chemistry, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Angiogenesis, Hexagonal boron nitrides, Polydopamine, Silver nanoparticles, Wound healing, 0105 earth and related environmental sciences, Tube formation, chemistry.chemical_classification, Reactive oxygen species, Wound Healing, Cell migration, chemistry, Biophysics, Molecular Medicine, Reactive Oxygen Species, 030217 neurology & neurosurgery |
الوصف: | Background Wound healing is an essential physiological process involving many cell types and their products acting in a marvellous harmony to repair damaged tissues. During the healing process, cellular proliferation and extracellular matrix remodelling stages could be interrupted by undesired factors including microorganisms and altered metabolic activities. In such a case, the process requires some external stimulants to accelerate or remediate the healing stages. Methods In this study, we report a multifunctional wound healing stimulating agent. In this context, hexagonal boron nitride (hBN) nanoparticles, silver nanoparticles (AgNPs) and polydopamine(pdopa) were used through mussel-inspired chemistry of dopamine to obtain pdopa coated hBN (hBN@pdopa) and AgNPs decorated hBN@pdopa (hBN@pdopa-AgNPs). These two nanostructures were investigated to observe stages of healing. Results AgNPs were chosen for inflammation reduction and hBN for induced cell proliferation and migration. In in vitro experiments, firstly, high cellular uptake capacity and biocompatibility of hBN@pdopa and hBN@pdopa-AgNPs were evaluated. They were also tested for their reaction against increased concentration of reactive oxygen species (ROS) in injured cells. Finally, their effect on cellular migration, intracellular tube formation and F-actin organization were monitored by light and confocal microscopy, respectively. Conclusion The results clearly indicate that the hBN@pdopa-AgNPs significantly decrease ROS production, promote wound closure, and reorganize tube formation in cells. |
وصف الملف: | application/pdf |
اللغة: | English |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e116a0163ad9991b7080aa3c8bf52b34 https://pubmed.ncbi.nlm.nih.gov/33984543/ |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....e116a0163ad9991b7080aa3c8bf52b34 |
قاعدة البيانات: | OpenAIRE |
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