CCR5-mediated Recruitment of NK Cells to the Kidney Is a Critical Step for Host Defense to Systemic Candida albicans Infection
| العنوان: | CCR5-mediated Recruitment of NK Cells to the Kidney Is a Critical Step for Host Defense to Systemic Candida albicans Infection |
|---|---|
| المؤلفون: | Jong S. Lee, Byungsuk Kwon, Minji Kim, Saerom Lee, Vuvi G. Tran, Nu Z. N. Nguyen, Hong R. Cho, Juyang Kim, Hye Jin Kim, Sang W. Kang |
| المصدر: | Immune Network |
| بيانات النشر: | The Korean Association of Immunologists, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Immunology, CD11c, NK cells, Dendritic cells, Microbiology, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Immune system, IL-23, Candida albicans, medicine, Interleukin 23, Immunology and Allergy, Kidney, biology, Effector, GM-CSF, biology.organism_classification, Corpus albicans, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Original Article, CCR5, 030215 immunology |
| الوصف: | C-C chemokine receptor type 5 (CCR5) regulates the trafficking of various immune cells to sites of infection. In this study, we showed that expression of CCR5 and its ligands was rapidly increased in the kidney after systemic Candida albicans infection, and infected CCR5-/- mice exhibited increased mortality and morbidity, indicating that CCR5 contributes to an effective defense mechanism against systemic C. albicans infection. The susceptibility of CCR5-/- mice to C. albicans infection was due to impaired fungal clearance, which in turn resulted in exacerbated renal inflammation and damage. CCR5-mediated recruitment of NK cells to the kidney in response to C. albicans infection was necessary for the anti-microbial activity of neutrophils, the main fungicidal effector cells. Mechanistically, C. albicans induced expression of IL-23 by CD11c+ dendritic cells (DCs). IL-23 in turn augmented the fungicidal activity of neutrophils through GM-CSF production by NK cells. As GM-CSF potentiated production of IL-23 in response to C. albicans, a positive feedback loop formed between NK cells and DCs seemed to function as an amplification point for host defense. Taken together, our results suggest that CCR5-mediated recruitment of NK cells to the site of fungal infection is an important step that underlies innate resistance to systemic C. albicans infection. |
| اللغة: | English |
| تدمد: | 2092-6685 1598-2629 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e250a25b3b6b1dbd84029d5eb354553e http://europepmc.org/articles/PMC7779867 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e250a25b3b6b1dbd84029d5eb354553e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20926685 15982629 |
|---|