Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
| العنوان: | Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study |
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| المؤلفون: | Michael Mackinley, Ali R. Khan, Lena Palaniyappan, Tushar Das, Peter Jeon, Avyarthana Dey, Kara Dempster, Joseph S. Gati |
| المصدر: | NPJ Schizophrenia npj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Psychiatry, Psychosis, Resting state fMRI, business.industry, Thought disorder, RC435-571, medicine.disease, Disease cluster, Article, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Schizophrenia, First episode psychosis, medicine, In patient, medicine.symptom, Centrality, business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Network-level dysconnectivity has been studied in positive and negative symptoms of schizophrenia. Conceptual disorganization (CD) is a symptom subtype that predicts impaired real-world functioning in psychosis. Systematic reviews have reported aberrant connectivity in formal thought disorder, a construct related to CD. However, no studies have investigated whole-brain functional correlates of CD in psychosis. We sought to investigate brain regions explaining the severity of CD in patients with first-episode psychosis (FEPs) compared with healthy controls (HCs). We computed whole-brain binarized degree centrality maps of 31 FEPs, 25 HCs, and characterized the patterns of network connectivity in the 2 groups. In FEPs, we related these findings to the severity of CD. We also studied the effect of positive and negative symptoms on altered network connectivity. Compared to HCs, reduced centrality of a right superior temporal gyrus (rSTG) cluster was observed in the FEPs. In patients exhibiting high CD, increased centrality of a medial superior parietal (mSPL) cluster was observed, compared to patients exhibiting low CD. This cluster was strongly correlated with CD scores but not with other symptom scores. Our observations are congruent with previous findings of reduced but not increased centrality. We observed increased centrality of mSPL suggesting that cortical reorganization occurs to provide alternate routes for information transfer. These findings provide insight into the underlying neural processes mediating the presentation of symptoms in untreated FEP. Longitudinal tracking of the symptom course will be useful to assess the mechanisms underlying these compensatory changes. |
| تدمد: | 2334-265X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e252d164959382fa3aaa3367ce865d3b https://pubmed.ncbi.nlm.nih.gov/33500416 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e252d164959382fa3aaa3367ce865d3b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 2334265X |
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