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Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi

التفاصيل البيبلوغرافية
العنوان: Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi
المؤلفون: Xing-Wei Yang, Man Wu, Yuanzhi Lao, Na-Na Jiang, Juan Zhang, Xia Liu, Gang Xu, Wenwei Fu, Hong-Xi Xu, Yan-Song Ye
المصدر: Natural Products and Bioprospecting, Vol 10, Iss 1, Pp 1-11 (2020)
Natural Products and Bioprospecting
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Cell cycle checkpoint, Dearomatized isoprenylated acylphloroglucinols (DIAPs), Apoptosis, Plant Science, 010402 general chemistry, Toxicology, 01 natural sciences, Biochemistry, Analytical Chemistry, Metastasis, Cell cycle arrest, lcsh:Botany, Mitophagy, medicine, Pharmacology, A549 cell, 010405 organic chemistry, Cell growth, Chemistry, Organic Chemistry, Autophagy, medicine.disease, In vitro, lcsh:QK1-989, 0104 chemical sciences, Hypericum henryi, Original Article, Food Science
الوصف: A series of dearomatized isoprenylated acylphloroglucinols derivatives, hyperhenols A–E (1–5), as well as seven known analogues (6–12), were characterized from Hypericum henryi. Their structures were determined by combination of NMR, ECD spectroscopy, and X-ray diffraction analysis. Compounds 1 and 6–8 were tested to exhibit potential antitumor properties, of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest. In addition, these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines, as well as suppress lung cancer A549 cells metastasis in vitro.
تدمد: 2192-2209
2192-2195
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38394a5b1334e9a9a51c9e64bb38590
https://doi.org/10.1007/s13659-019-00229-w
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....e38394a5b1334e9a9a51c9e64bb38590
قاعدة البيانات: OpenAIRE
الوصف
تدمد:21922209
21922195