The mechanically enhanced phase separation of sprayed polyurethane scaffolds and their effect on the alignment of fibroblasts
| العنوان: | The mechanically enhanced phase separation of sprayed polyurethane scaffolds and their effect on the alignment of fibroblasts |
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| المؤلفون: | Richard A. Lasher, Robert W. Hitchcock, James P. Kennedy, Sean P. McCandless |
| المصدر: | Biomaterials. 31:1126-1132 |
| بيانات النشر: | Elsevier BV, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Scaffold, Materials science, Fabrication, Surface Properties, Polyurethanes, Composite number, Cell Culture Techniques, Biophysics, Biocompatible Materials, Bioengineering, Phase Transition, Absorption, Biomaterials, Mice, chemistry.chemical_compound, Tissue engineering, Biomimetic Materials, Elastic Modulus, Tensile Strength, Materials Testing, Animals, Particle Size, Composite material, Anisotropy, Porosity, Elastic modulus, Polyurethane, Tissue Engineering, technology, industry, and agriculture, Cell Polarity, 3T3 Cells, Fibroblasts, chemistry, Mechanics of Materials, Ceramics and Composites, Gases, Crystallization |
| الوصف: | This paper reports a method to fabricate anisotropic scaffolds of tunable porosity and mechanical properties. Scaffolds were fabricated using a computer controlled sprayed phase separation technique. Following fabrication, the sheets were elongated 0, 35 or 70% of their original length to induce varying degrees of scaffold alignment and anisotropy. The nonsolvent used in the phase separation was shown to affect porosity and the elastic modulus. Mouse embryo NIH-3T3 fibroblasts were cultured on the scaffolds to investigate cell response to the anisotropy of the scaffold. A 2D FFT method was used to quantify cellular alignment. Cells were shown to align themselves with the scaffold. This sheet-like scaffold material can be used in single plys or can be laminated to form porous 3D composite scaffolds. |
| تدمد: | 0142-9612 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a956f0bf05aba16b174a82ee5bc1b0 https://doi.org/10.1016/j.biomaterials.2009.10.024 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e3a956f0bf05aba16b174a82ee5bc1b0 |
| قاعدة البيانات: | OpenAIRE |
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