Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution
العنوان: | Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution |
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المؤلفون: | Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere, Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches |
المصدر: | Science |
سنة النشر: | 2022 |
مصطلحات موضوعية: | Ambystoma mexicanum, Neurons, Multidisciplinary, Animals, Brain, Lizards, Transcriptome, Biological Evolution, Article |
الوصف: | The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander Pleurodeles waltl . Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR. |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c9162badf036225ca3dd2b4cf1bf66 https://lirias.kuleuven.be/handle/20.500.12942/711893 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....e3c9162badf036225ca3dd2b4cf1bf66 |
قاعدة البيانات: | OpenAIRE |
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